Nagai Emiko, Iwai Miwa, Koketsu Ritsuko, Sogabe Riho, Morimoto Ryosuke, Suzuki Yuri, Ohta Yoichiro, Okuno Yoshinobu, Ohshima Atsushi, Enomoto Toshiki, Isegawa Yuji
Department of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Department of Food Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
J Sci Food Agric. 2018 Mar;98(5):1899-1905. doi: 10.1002/jsfa.8671. Epub 2017 Oct 12.
The present study was conducted aiming to examine the antiviral activity of adlay tea and its components against influenza viruses. We further aimed to clarify the mechanism by which these components regulate virus replication.
Adlay tea at a concentration suitable for drinking inhibited the multiplication of influenza viruses. Moreover, our results suggest that individual components of the tea had antiviral activities against the influenza A/PR/8/34 virus. Adlay tea inhibited multiplication of the H1N1, H3N2 and B types of influenza virus, including oseltamivir-resistant viruses. In addition, adlay tea inhibited influenza infection during the periods of virus adsorption to the cell and virus replication. Adlay tea did not suppress hemagglutination inhibition or cell fusion, although it slightly inhibited virus binding to Malin Darby canine kidney cells. Furthermore, our findings suggest that the antiviral compounds included in adlay tea were ingredients other than polyphenols and that there were several types of effective compounds in adlay tea inhibiting several steps of viral replication.
The results of the present study demonstrate that adlay tea had antiviral effects against influenza viruses. Our findings with respect to adlay tea suggest that the polyphenols might have a small influence on its antiviral activity and that other ingredients might have more influence. © 2017 Society of Chemical Industry.
本研究旨在检测薏仁茶及其成分对流感病毒的抗病毒活性。我们还旨在阐明这些成分调节病毒复制的机制。
浓度适宜饮用的薏仁茶可抑制流感病毒的增殖。此外，我们的结果表明，薏仁茶的各个成分对甲型流感病毒A/PR/8/34具有抗病毒活性。薏仁茶可抑制H1N1、H3N2和B型流感病毒的增殖，包括对奥司他韦耐药的病毒。此外，薏仁茶在病毒吸附到细胞和病毒复制期间可抑制流感感染。薏仁茶虽轻微抑制病毒与玛林-达比犬肾细胞的结合，但不抑制血凝抑制或细胞融合。此外，我们的研究结果表明，薏仁茶中的抗病毒化合物不是多酚类成分，且薏仁茶中有几种有效化合物可抑制病毒复制的多个步骤。
本研究结果表明薏仁茶对流感病毒具有抗病毒作用。我们对薏仁茶的研究结果表明，多酚类成分可能对其抗病毒活性影响较小，而其他成分可能影响更大。© 2017化学工业协会。
