Suppr超能文献

长期耐力运动可对抗癸酸诺龙诱导的心脏UCP2和UCP3蛋白上调。

Chronic endurance exercise antagonizes the cardiac UCP2 and UCP3 protein up-regulation induced by nandrolone decanoate.

作者信息

Bayat Gholamreza, Javan Mohammad, Khalili Azadeh, Safari Fatemeh, Shokri Saeed, Hajizadeh Sohrab

机构信息

.

出版信息

J Basic Clin Physiol Pharmacol. 2017 Nov 27;28(6):609-614. doi: 10.1515/jbcpp-2017-0049.

Abstract

BACKGROUND

Several lines of evidence revealed that chronic treatment of anabolic androgenic steroids (AASs) is accompanied with some cardiovascular side effects and in addition they also negatively mask the beneficial effects of exercise training on cardiac performance.

METHODS

The present study examined whether the nandrolone decanoate (ND)-induced cardiac effects were mediated by changing the cardiac uncoupling protein 2 (UCP2) and 3 (UCP3) expression. Five groups of male wistar-albino rats including sedentary control (SC), sedentary vehicle (SV), sedentary nandrolone decanoate (SND), exercise control (EC), and exercise nandrolone decanoate (END) were used. ND was injected (10 mg/kg/week, intramuscular) to the animals in the SND and END groups and endurance exercise training was performed on a treadmill five times per week.

RESULTS

The protein expressions of cardiac UCP2 and UCP3 have significantly increased in both the SND and EC groups compared to the SC ones. In contrast to UCP3, no significant differences were found between UCP2 protein expressions of the END and SC groups. Compared with the SND group, the exercise training significantly decreased the UCP2 and UCP3 protein expressions in the END group.

CONCLUSIONS

The study has indicated that endurance exercise in combination with ND can result in that the exercise effectively antagonizes the effects of ND treatment on UCP2 and UCP3 up-regulation.

摘要

背景

多项证据表明,长期使用合成代谢雄激素类固醇(AASs)会伴随一些心血管副作用,此外,它们还会负面掩盖运动训练对心脏功能的有益影响。

方法

本研究检测了癸酸诺龙(ND)诱导的心脏效应是否通过改变心脏解偶联蛋白2(UCP2)和3(UCP3)的表达来介导。使用了五组雄性Wistar白化大鼠,包括久坐对照组(SC)、久坐溶剂组(SV)、久坐癸酸诺龙组(SND)、运动对照组(EC)和运动癸酸诺龙组(END)。对SND组和END组的动物注射ND(10mg/kg/周,肌肉注射),并每周在跑步机上进行五次耐力运动训练。

结果

与SC组相比,SND组和EC组心脏UCP2和UCP3的蛋白表达均显著增加。与UCP3不同,END组和SC组UCP2蛋白表达之间未发现显著差异。与SND组相比,运动训练显著降低了END组UCP2和UCP3的蛋白表达。

结论

该研究表明,耐力运动与ND联合使用可使运动有效拮抗ND治疗对UCP2和UCP3上调的影响。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验