Division of General Internal Medicine, Weill Cornell Medicine of Cornell University, New York, New York.
Department of Neurosurgery, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e123-e133. doi: 10.1093/jpids/pix059.
Although uncommon in children, fungal infections of the central nervous system can be devastating and difficult to treat. A better understanding of basic mycologic, immunologic, and pharmacologic processes has led to important advances in the diagnosis and management of these diseases, but their mortality rates remain unacceptably high. In this focused review, we examine the epidemiology and clinical features of the most common fungal pathogens of the central nervous system in children and explore recent advances in diagnosis and antifungal therapy.
虽然真菌性中枢神经系统感染在儿童中不常见，但可能具有破坏性且难以治疗。对基础的微生物学、免疫学和药理学过程的更好理解，推动了这些疾病的诊断和治疗方面的重要进展，但它们的死亡率仍然高得不可接受。在本次重点综述中，我们研究了儿童中枢神经系统最常见真菌病原体的流行病学和临床特征，并探讨了诊断和抗真菌治疗方面的最新进展。
