Abdel-Malek Khaled, El-Halwagi Mohamed Ahmed, Hammad Bahaa Eldin, Azmy Osama, Helal Omneya, Eid Marwa, Abdel-Rasheed Mazen
a Department of Obstetrics and Gynecology, Faculty of Medicine , Cairo University , Cairo , Egypt.
b Department of Reproductive Health Research , National Research Centre , Cairo , Egypt.
J Obstet Gynaecol. 2018 Feb;38(2):222-225. doi: 10.1080/01443615.2017.1347915. Epub 2017 Sep 14.
The aim of this study was to evaluate the value of measurement of serum ferritin level in pregnant women to predict preterm labour. The study included 236 women whose haemoglobin (Hb) levels were ≥10.5 gm/dl and gestational age (GA) was less than 30 weeks. Serum ferritin levels were measured at 30 weeks of gestational age. At the end of the study, 23 women delivered with preterm premature rupture of membrane (PPROM) and 17 women delivered before 37 weeks but without PROM (study group). The rest of the pregnant women (196 women) delivered between 37 and 40 weeks (control group). We found a significant difference between the two groups with respect to serum ferritin level. The cut off value of serum ferritin between the two groups was 31 ng/ml with sensitivity 92.8%, specificity 99.4%, positive predictive value 97.5%, negative predictive value 98.4% and accuracy 98.3%. Impact statement What is already known on this subject: maternal serum ferritin has been found to be elevated in women who delivered preterm. What the results of this study add: In this study, we have shown that serum ferritin 31 ng/ml is the optimal cut-point between preterm and full-term women. What the implications are of these findings for clinical practice and/or further research: Serum ferritin 31 ng/ml could be proposed as a potential helpful marker to predict preterm labour.
本研究的目的是评估检测孕妇血清铁蛋白水平对预测早产的价值。该研究纳入了236名血红蛋白(Hb)水平≥10.5克/分升且孕周(GA)小于30周的女性。在孕30周时检测血清铁蛋白水平。研究结束时,23名女性发生胎膜早破早产(PPROM),17名女性在37周前分娩但未发生胎膜早破(研究组)。其余孕妇(196名女性)在37至40周之间分娩(对照组)。我们发现两组之间血清铁蛋白水平存在显著差异。两组之间血清铁蛋白的临界值为31纳克/毫升,敏感性为92.8%,特异性为99.4%,阳性预测值为97.5%,阴性预测值为98.4%,准确性为98.3%。影响声明关于该主题已知的信息:已发现早产女性的母体血清铁蛋白升高。本研究的结果补充了什么:在本研究中,我们表明血清铁蛋白31纳克/毫升是早产和足月女性之间的最佳切点。这些发现对临床实践和/或进一步研究的意义是什么:血清铁蛋白31纳克/毫升可被提议作为预测早产的潜在有用标志物。