International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University , Uppsala, Sweden.
Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research , Dhaka, Bangladesh.
Glob Health Action. 2021 Jan 1;14(1):1870421. doi: 10.1080/16549716.2020.1870421.
: Iron supplementation in pregnancy is recommended by the WHO to prevent a major public health problem, namely, maternal iron deficiency and its consequences. There are gaps in the existing evidence regarding maternal and neonatal benefits and harms of universal iron supplementation. : To evaluate the association between maternal iron status during pregnancy and infant size at birth (birth weight and length). : This present prospective cohort study was nested in a food and micronutrient supplementation trial conducted in Matlab (MINIMat study), rural Bangladesh. We randomly selected 573 women recruited into the MINIMat study from January - December 2002 who delivered singletons with available birth anthropometric information. The plasma ferritin of each mother was measured at gestational week 14 (GW14; before the start of micronutrient supplementation) and at week 30 (GW30). : Multivariable linear regression revealed no association between plasma ferritin at GW14 and birth weight. However, newborns of women in the highest tertile of plasma ferritin at GW30 (median = 29 µg/L) had on average a 93-gm lower birth weight (95% CI: -172, - 14; = 0.021) than the newborns of womehemoglobin (Hb) synthesisn in the lowest tertile (median = 8 µg/L). Logistic regression showed that odds of low birth weight were approximately two times higher [odds ratio (OR) = 2.27; 95% CI: 1.40, 3.67] among those with mothers in the highest ferritin tertile than in the lowest tertile at GW30. No association was found between maternal plasma ferritin and birth length. : We observed an inverse association between high plasma ferritin in the last trimester (GW30) and birth weight but not birth length. The results suggested that elevated plasma ferritin in pregnancy could have an untoward effect on birth weight.
: 世界卫生组织建议孕妇补铁，以预防缺铁这一重大公共卫生问题及其后果。目前，关于普遍补铁对母婴的益处和危害的证据仍存在空白。: 评估孕妇妊娠期铁状况与婴儿出生时体重（出生体重和身长）的关系。: 本前瞻性队列研究嵌套在孟加拉国 Matlab 进行的一项食物和微量营养素补充试验（MINIMat 研究）中。我们随机选择了 2002 年 1 月至 12 月期间招募的 573 名 MINIMat 研究中的单胎孕妇，这些孕妇提供了出生人体测量信息。每位母亲的血浆铁蛋白在妊娠第 14 周（GW14；微量营养素补充开始前）和第 30 周（GW30）进行测量。: 多变量线性回归显示，GW14 时的血浆铁蛋白与出生体重之间无关联。然而，GW30 时铁蛋白处于最高三分位的女性所生的新生儿的出生体重平均低 93 克（95%CI：-172，-14；=0.021），低于铁蛋白处于最低三分位的女性所生的新生儿（中位=8μg/L）。逻辑回归显示，在 GW30 时处于最高铁蛋白三分位的女性中，出生体重较低的可能性大约是处于最低三分位的女性的两倍[比值比（OR）=2.27；95%CI：1.40，3.67]。未发现母体血浆铁蛋白与出生体长之间存在关联。: 我们观察到，妊娠晚期（GW30）高血浆铁蛋白与出生体重呈负相关，但与出生体长无关。结果表明，妊娠期间血浆铁蛋白升高可能对出生体重产生不利影响。
