Metabolic changes induced by acute phosphate loading in acutely thyroparathyroidectomized rats.

Phosphate loading in acutely thyroparathyroidectomized rats is followed by a decline of phosphate reabsorption. In addition, a mixed respiratory and metabolic alkalosis and hypocalcemia develop. Normalization of plasma calcium concentration, unlike the reversal of the alkalosis, prevents the fall in phosphate reabsorption.