Yamane Keishi, Kawasaki Yukihiko, Maeda Ryo, Ohara Shinichiro, Suyama Kazuhide, Hosoya Mitsuaki
Department of Pediatrics, Fukushima Medical University School of Medicine.
Fukushima J Med Sci. 2017 Dec 19;63(3):135-140. doi: 10.5387/fms.2017-14. Epub 2017 Sep 14.
To evaluate the recent frequency of onset and severity of IgA vasculitis with nephritis (IgAVN) in Fukushima Prefecture, we examined the epidemiology and clinico-pathological manifestations of IgAVN in our hospital over a 10-year period.
We enrolled 18 patients with IgAVN treated between 2004 and 2013 in the Department of Pediatrics, Fukushima Medical University School of Medicine. These patients were divided into two groups; Group 1 consisted of 12 patients with IgAVN hospitalized between 2004 and 2008 and Group 2 consisted of 6 patients with IgAVN hospitalized between 2009 and 2013. The epidemiology, clinical features, laboratory data, pathological findings, and outcome were retrospectively compared between the two groups.
The numbers of patients with IgAVN per year in Group 2 were lower than that in Group 1. The frequency of patients with higher than grade IIIb disease in Group 2 (50%) was lower than that in Group 1 (94%); furthermore, the frequency of patients with higher than grade IV disease in Group 2 (0%) was lower than that in Group 1 (50%).
Our findings suggest that the incidence of onset and severity of IgAVN in patients diagnosed between 2009 and 2013 were lower than those in patients diagnosed between 2004 and 2008.
为评估福岛县IgA血管炎伴肾炎（IgAVN）近期的发病频率和严重程度，我们对我院10年间IgAVN的流行病学和临床病理表现进行了研究。
我们纳入了2004年至2013年期间在福岛医科大学医学院儿科接受治疗的18例IgAVN患者。这些患者被分为两组；第1组由2004年至2008年住院的12例IgAVN患者组成，第2组由2009年至2013年住院的6例IgAVN患者组成。对两组患者的流行病学、临床特征、实验室数据、病理结果及转归进行回顾性比较。
第2组每年的IgAVN患者数量低于第1组。第2组中疾病严重程度高于Ⅲb级的患者频率（50%）低于第1组（94%）；此外，第2组中疾病严重程度高于Ⅳ级的患者频率（0%）低于第1组（50%）。
我们的研究结果表明，2009年至2013年诊断的IgAVN患者的发病发病率和严重程度低于2004年至2008年诊断的患者。
