Agrawal C, Sood V, Kumar A, Raghavan V
Department of Internal Medical, Armed Forces Medical College, Pune, Maharashtra, India.
Department of Nephrology, Armed Forces Medical College, Pune, Maharashtra, India.
Indian J Nephrol. 2017 Sep-Oct;27(5):392-394. doi: 10.4103/ijn.IJN_298_16.
Invasive fungal infections (IFIs) are a significant cause of morbidity in solid organ transplant (SOT) recipients. Common causes among them are , , and . Antifungal prophylaxis has led to decrease in overall incidence of IFI; however, there is very little decline in the incidence of Cryptococcal infections of SOT recipients because effective prophylaxis is not available against this infectious agent. Spectrum of manifestation of Cryptococcal infection varies in immunocompetent and immunocompromised host with subclinical and self-limiting with lungs being the primary site in immunocompetent and central nervous system as the most common site in an immunocompromised host. Other preferred sites are cutaneous, pulmonary, urinary tract (prostate) and the bone. Herein, we describe a young adult renal transplant recipient male diagnosed as a rare case of biopsy proven Cryptococcal infection in transplant kidney manifesting as chronic allograft dysfunction.
侵袭性真菌感染（IFI）是实体器官移植（SOT）受者发病的重要原因。其中常见病因有 、 以及 。抗真菌预防措施已使IFI的总体发病率有所下降；然而，SOT受者隐球菌感染的发病率几乎没有下降，因为尚无针对这种感染病原体的有效预防措施。隐球菌感染在免疫功能正常和免疫功能低下宿主中的表现谱有所不同，在免疫功能正常宿主中呈亚临床和自限性，肺部是主要发病部位，而在免疫功能低下宿主中，中枢神经系统是最常见的发病部位。其他好发部位为皮肤、肺部、泌尿道（前列腺）和骨骼。在此，我们描述了一名年轻成年男性肾移植受者，经活检证实为移植肾罕见的隐球菌感染病例，表现为慢性移植肾失功。
