Jackson Katrina M, Ding Minna, Nielsen Kirsten
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
J Fungi (Basel). 2023 Mar 16;9(3):364. doi: 10.3390/jof9030364.
The human pathogenic fungus is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study , describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host-pathogen interaction during infection.
人类致病真菌是一个全球健康问题。该领域以前的研究主要集中在使用参考菌株来鉴定毒力因子、构建突变体文库、确定基因组结构以及进行功能研究。在这篇综述中，我们讨论了使用参考菌株进行研究的利弊，描述了对临床分离株的研究如何扩展了我们对发病机制的理解，并强调了使用临床分离株的研究如何能进一步深化我们对感染期间宿主-病原体相互作用的理解。
