Suppr超能文献

碳-碳键和碳-氮键的氧化脱氢反应:一种合成多种(二氢)杂芳族化合物的便捷方法。

Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro)heteroaromatic compounds.

作者信息

Hati Santanu, Holzgrabe Ulrike, Sen Subhabrata

机构信息

Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Dadri, Chithera, GautamBuddha Nagar, Uttar Pradesh 201314, India.

Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

出版信息

Beilstein J Org Chem. 2017 Aug 15;13:1670-1692. doi: 10.3762/bjoc.13.162. eCollection 2017.

Abstract

Nitrogen heteroarenes form an important class of compounds which can be found in natural products, synthetic drugs, building blocks etc. Among the diverse strategies that were developed for the synthesis of nitrogen heterocycles, oxidative dehydrogenation is extremely effective. This review discusses various oxidative dehydrogenation strategies of C-C and C-N bonds to generate nitrogen heteroarenes from their corresponding heterocyclic substrates. The strategies are categorized under stoichiometric and catalytic usage of reagents that facilitate such transformations. The application of these strategies in the synthesis of nitrogen heteroarene natural products and synthetic drug intermediates are also discussed. We hope this review will arouse sufficient interest among the scientific community to further advance the application of oxidative dehydrogenation in the synthesis of nitrogen heteroarenes.

摘要

氮杂芳烃构成了一类重要的化合物,可存在于天然产物、合成药物、结构单元等中。在为合成氮杂环而开发的各种策略中,氧化脱氢极其有效。本综述讨论了通过碳 - 碳和碳 - 氮键的各种氧化脱氢策略,以从其相应的杂环底物生成氮杂芳烃。这些策略根据促进此类转化的试剂的化学计量和催化用途进行分类。还讨论了这些策略在氮杂芳烃天然产物和合成药物中间体合成中的应用。我们希望本综述能引起科学界的足够兴趣,以进一步推进氧化脱氢在氮杂芳烃合成中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b434/5564259/cd2838b4e15f/Beilstein_J_Org_Chem-13-1670-g002.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验