Anoun Nadia, El Ouahabi Hanan
Service d'Endocrinologie, Diabétologie et Nutrition, CHU Hassan II de Fès, Maroc.
Equipe Sciences des Médicaments, Centre Médical de Recherche Biomédicale et Translationnelle, Faculté de Médecine et de Pharmacie de Fès, Maroc.
Pan Afr Med J. 2017 Jul 4;27:169. doi: 10.11604/pamj.2017.27.169.11518. eCollection 2017.
Somatotroph adenomas are rare in the aging population. Diagnosis of somatotroph adenomas is often long delayed and they are characterized by atypical clinical picture. Their diagnostic criteria are similar to those used for younger patients. Surgery, if possible, is the treatment of choice for acromegaly in the elderly. Somatostatin analogues have shown to be effective in these patients. Prognosis is inversely correlated with patient's age, duration of disease and last GH level under treatment. Beside evolution of disease, age is a major determinant of mortality. We report three cases of elderly patients with acromegaly aged 75, 70 and 66 years respectively with a literature review.
生长激素腺瘤在老年人群中较为罕见。生长激素腺瘤的诊断往往延迟很久，且具有非典型的临床表现。其诊断标准与用于年轻患者的标准相似。若有可能，手术是老年肢端肥大症患者的首选治疗方法。生长抑素类似物已被证明对这些患者有效。预后与患者年龄、病程及治疗期间的最后生长激素水平呈负相关。除了疾病进展外，年龄是死亡率的主要决定因素。我们报告了三例分别为75岁、70岁和66岁的老年肢端肥大症患者，并进行了文献综述。
