血管紧张素II的渗透调节作用独立于绿头鸭（Anas platyrhynchos）的肾上腺素能受体机制。

Osmoregulatory actions of angiotensin II are independent of adrenergic receptor mechanisms in the duck, Anas platyrhynchos.

Wilson J X

Department of Physiology, University of Saskatchewan, Saskatoon, Canada.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;88(1):57-60. doi: 10.1016/0742-8413(87)90046-6.

Abstract

Intravenous infusion of a physiological dose of fowl angiotensin II (ANG II) in salt-loaded ducks raised systemic arterial blood pressure, inhibited nasal salt gland fluid and solute secretion, and stimulated renal-cloacal urine production. 2. Beta-adrenergic receptor blockade by propranolol lowered arterial pressure but did not prevent the effects of ANG II on salt and water excretion. 3. Alpha-adrenergic receptor blockade by prazosin decreased both arterial pressure and plasma glucose levels, but it did not impair the osmoregulatory actions of ANG II. 4. These observations indicate that redistribution by ANG II of salt and water excretion is independent of adrenergic receptor mechanisms and therefore does not depend on the sympathomimetic activity of the hormone.

摘要

给盐负荷鸭静脉输注生理剂量的禽血管紧张素II（ANG II）可升高体循环动脉血压，抑制鼻盐腺液体和溶质分泌，并刺激肾-泄殖腔尿液生成。2. 普萘洛尔对β-肾上腺素能受体的阻断降低了动脉压，但并未阻止ANG II对盐和水排泄的影响。3. 哌唑嗪对α-肾上腺素能受体的阻断降低了动脉压和血浆葡萄糖水平，但并未损害ANG II的渗透调节作用。4. 这些观察结果表明，ANG II对盐和水排泄的重新分配与肾上腺素能受体机制无关，因此不依赖于该激素的拟交感活性。