Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, 1941 East Road, Suite 3128, Houston, TX, 77054, USA.
Eur Child Adolesc Psychiatry. 2018 Mar;27(3):267-277. doi: 10.1007/s00787-017-1045-4. Epub 2017 Sep 13.
An association between primary headaches and attention-deficit/hyperactivity disorder (ADHD) has long been suggested. Moreover, headache is regarded as a common side effect of stimulants, the most effective treatment for ADHD. So far, no systematic review has evaluated the potential association between ADHD and headache. We performed a systematic review of the literature and a meta-analysis of all reported studies on ADHD and primary headaches. Our analysis showed a positive association between ADHD and migraine (OR 1.322, 95% CI 1.018-1717, p value 0.036), but not with tension-type headache. There is a significant association between migraine and ADHD. The mechanisms underlying this association remain to be elucidated, warranting further studies.
长期以来，人们一直认为原发性头痛与注意力缺陷多动障碍（ADHD）之间存在关联。此外，头痛被认为是兴奋剂的常见副作用，而兴奋剂是治疗 ADHD 最有效的药物。到目前为止，尚无系统评价评估 ADHD 和头痛之间的潜在关联。我们对 ADHD 和原发性头痛的所有报告研究进行了系统的文献回顾和荟萃分析。我们的分析表明，ADHD 与偏头痛之间存在正相关（OR 1.322，95%CI 1.018-1717，p 值 0.036），但与紧张型头痛无关。偏头痛和 ADHD 之间存在显著关联。这种关联的潜在机制仍有待阐明，需要进一步的研究。
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