Department of Biomedical Sciences for Health, IRCCS Policlinico San Donato, University of Milan, Piazza E. Malan 1, San Donato Mil.se, 20097, Milan, Italy.
J Neurovirol. 2017 Dec;23(6):922-928. doi: 10.1007/s13365-017-0575-3. Epub 2017 Sep 13.
A 56-year-old immunocompetent male developed brainstem encephalitis complicating Ramsay Hunt syndrome. The disease had a slowly progressing course of months after the triggering infection, much longer than previously reported. Furthermore, magnetic resonance imaging, physical-chemical, and cell count analyses on cerebrospinal fluid were normal, whereas polymerase chain reaction for varicella zoster virus DNA was positive. The simultaneous negativity of both imaging and basic CSF exams is very rare, although possible event which confirms the irreplaceable role of viral screening on CSF. A systematic review of similar reports with highlights on the unusual aspects of our case is also presented.
一位 56 岁免疫功能正常的男性发生了脑干部位脑炎,并发拉姆齐亨特综合征。在触发感染后,疾病呈数月的缓慢进展过程,比之前报道的时间都要长。此外,患者的脑脊液的理化性质和细胞计数分析均正常,但单纯疱疹病毒 DNA 的聚合酶链反应呈阳性。影像学和基本脑脊液检查同时呈阴性的情况非常罕见,但本例的这种特殊情况证实了病毒筛查脑脊液的不可替代的作用。本文还对类似病例进行了系统综述,并重点介绍了本病例的特殊之处。