Chan Tommy L H, Cartagena Ana M, Bombassaro Anne Marie, Hosseini-Moghaddam Seyed M
Department of Clinical Neurological Sciences, London Health Sciences Centre (LHSC), London, ON, Canada.
Pharmacy Services, London Health Sciences Centre (LHSC) and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Can J Infect Dis Med Microbiol. 2016;2016:9859816. doi: 10.1155/2016/9859816. Epub 2016 Apr 13.
Ramsay Hunt syndrome associated with varicella zoster virus reactivation affecting the central nervous system is rare. We describe a 55-year-old diabetic female who presented with gait ataxia, right peripheral facial palsy, and painful vesicular lesions involving her right ear. Later, she developed dysmetria, fluctuating diplopia, and dysarthria. Varicella zoster virus was detected in the cerebrospinal fluid by polymerase chain reaction. She was diagnosed with Ramsay Hunt syndrome associated with spread to the central nervous system. Her facial palsy completely resolved within 48 hours of treatment with intravenous acyclovir 10 mg/kg every 8 hours. However, cerebellar symptoms did not improve until a tapering course of steroid therapy was initiated.
与水痘-带状疱疹病毒再激活累及中枢神经系统相关的拉姆齐·亨特综合征很罕见。我们描述了一名55岁的糖尿病女性，她出现步态共济失调、右侧周围性面瘫以及累及右耳的疼痛性水疱性病变。后来，她出现了辨距不良、波动性复视和构音障碍。通过聚合酶链反应在脑脊液中检测到水痘-带状疱疹病毒。她被诊断为与扩散至中枢神经系统相关的拉姆齐·亨特综合征。在每8小时静脉注射10mg/kg阿昔洛韦治疗48小时内，她的面瘫完全缓解。然而，直到开始逐渐减量的类固醇治疗疗程，小脑症状才有所改善。
