Bivona Joseph J, Patel Sapna, Vajdy Michael
a EpitoGenesis, Inc , Vernon , CT , USA.
b Department of Medicine , University of Vermont , Burlington , VT , USA.
Expert Opin Biol Ther. 2017 Dec;17(12):1539-1551. doi: 10.1080/14712598.2017.1375096. Epub 2017 Sep 14.
Vitamins E and C are well known small molecules that have been used to maintain health for decades. Recent studies of the cellular and molecular pathways leading to immunomodulation by these molecules have been of interest, as have their anti-oxidant properties and signal transduction pathways for curing or improving infectious diseases and cancer. Areas covered: Herein, the authors provide a definition and the structural classification of vitamins E and C and how these molecules influence cellular function. The studies include in vitro, ex vivo and in vivo studies in animal models as well as clinical trials. The authors give particular focus to the scientifically factual and putative roles of these molecules in innate and adaptive immunomodulation and prevention or cure of diseases. Expert opinion: The antioxidant properties of vitamins E and C are well studied. However, whether there is a link between their antioxidant and immunomodulation properties is unclear. In addition, there is a strong, albeit putative, prevailing notion that vitamin C can prevent or cure infectious diseases or cancer. Presently, while there is proven evidence that vitamin E possesses immunomodulatory properties that may play a positive role in disease outcomes, this evidence is less available for vitamin C.
维生素E和维生素C是众所周知的小分子，数十年来一直被用于维持健康。近年来，关于这些分子导致免疫调节的细胞和分子途径的研究备受关注，它们的抗氧化特性以及用于治疗或改善传染病和癌症的信号转导途径也同样如此。涵盖领域：在此，作者给出了维生素E和维生素C的定义、结构分类，以及这些分子如何影响细胞功能。这些研究包括在动物模型中的体外、离体和体内研究以及临床试验。作者特别关注这些分子在固有免疫和适应性免疫调节以及疾病预防或治疗方面的科学事实和假定作用。专家观点：维生素E和维生素C的抗氧化特性已得到充分研究。然而，它们的抗氧化特性与免疫调节特性之间是否存在联系尚不清楚。此外，尽管只是一种假定，但有一种普遍的观点认为维生素C可以预防或治愈传染病或癌症。目前，虽然有证据证明维生素E具有免疫调节特性，可能对疾病转归起到积极作用，但关于维生素C的此类证据较少。
