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Bivalirudin for patients with STEMI at high risk of bleeding undergoing PPCI.

作者信息

Hu Lu, Guo Kai, Guo Zhigang

机构信息

Department of Cardiology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou 510515, Guangdong Province, China.

出版信息

Nat Rev Cardiol. 2017 Sep 14;14(10):626. doi: 10.1038/nrcardio.2017.141.

DOI:10.1038/nrcardio.2017.141
PMID:28905940
Abstract
摘要

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Bivalirudin for patients with STEMI at high risk of bleeding undergoing PPCI.比伐卢定用于接受直接经皮冠状动脉介入治疗（PPCI）且有高出血风险的ST段抬高型心肌梗死（STEMI）患者。
Nat Rev Cardiol. 2017 Sep 14;14(10):626. doi: 10.1038/nrcardio.2017.141.
2
Outcomes in elderly and young patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with bivalirudin versus heparin: Pooled analysis from the EUROMAX and HORIZONS-AMI trials.使用比伐卢定与肝素进行直接经皮冠状动脉介入治疗的老年和年轻ST段抬高型心肌梗死患者的预后：来自EUROMAX和HORIZONS-AMI试验的汇总分析
Am Heart J. 2017 Dec;194:73-82. doi: 10.1016/j.ahj.2017.08.009. Epub 2017 Aug 18.
3
Heparin Versus Bivalirudin Monotherapy in the Setting of Primary Percutaneous Coronary Intervention for Patients With ST-Segment Elevation Myocardial Infarction.在ST段抬高型心肌梗死患者的直接经皮冠状动脉介入治疗中肝素与比伐卢定单药治疗的比较
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4
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Cardiovasc Ther. 2017 Jun;35(3). doi: 10.1111/1755-5922.12251.
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Meta-analysis of randomized clinical trials comparing bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention and in patients with ST-segment elevation myocardial infarction.经皮冠状动脉介入治疗和 ST 段抬高型心肌梗死患者中比伐卢定与肝素加糖蛋白 IIb/IIIa 抑制剂比较的随机临床试验的荟萃分析。
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Utilization of anticoagulants and outcomes in STEMI patients undergoing PPCI in the US hospitals: Bivalirudin, heparin plus GPI or heparin alone?美国医院中接受直接经皮冠状动脉介入治疗的ST段抬高型心肌梗死患者使用抗凝剂情况及预后：比伐卢定、肝素加糖蛋白抑制剂还是单用肝素？
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Arch Cardiovasc Dis. 2016 Dec;109(12):696-707. doi: 10.1016/j.acvd.2015.10.007. Epub 2016 Nov 3.

引用本文的文献

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Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study.比伐卢定桥接依诺肝素与磺达肝癸钠在接受直接经皮冠状动脉介入治疗的急性心肌梗死患者中的疗效和安全性：一项单中心研究的证据
Arch Med Sci. 2023 Jan 13;19(1):242-249. doi: 10.5114/aoms/157287. eCollection 2023.

本文引用的文献

1
Antithrombotic therapy for patients with STEMI undergoing primary PCI.ST段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗的抗栓治疗。
Nat Rev Cardiol. 2017 Jun;14(6):361-379. doi: 10.1038/nrcardio.2017.18. Epub 2017 Feb 23.
2
Bivalirudin or unfractionated heparin in patients with acute coronary syndromes managed invasively with and without ST elevation (MATRIX): randomised controlled trial.急性冠脉综合征患者行有创治疗伴或不伴ST段抬高时使用比伐卢定或普通肝素（MATRIX）：随机对照试验
BMJ. 2016 Sep 27;354:i4935. doi: 10.1136/bmj.i4935.
3
Prolonged High-Dose Bivalirudin Infusion Reduces Major Bleeding Without Increasing Stent Thrombosis in Patients Undergoing Primary Percutaneous Coronary Intervention: Novel Insights From an Updated Meta-Analysis.
延长高剂量比伐卢定输注可减少接受直接经皮冠状动脉介入治疗患者的大出血且不增加支架内血栓形成：一项更新的荟萃分析的新见解
J Am Heart Assoc. 2016 Jul 22;5(7):e003515. doi: 10.1161/JAHA.116.003515.
4
Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk.高出血风险患者的无聚合物涂层药物洗脱冠状动脉支架。
N Engl J Med. 2015 Nov 19;373(21):2038-47. doi: 10.1056/NEJMoa1503943. Epub 2015 Oct 14.
5
Novel approaches for preventing or limiting events (Naples) III trial: randomized comparison of bivalirudin versus unfractionated heparin in patients at increased risk of bleeding undergoing transfemoral elective coronary stenting.新型预防或限制事件（那不勒斯）III 期临床试验：经股动脉择期冠状动脉支架置入术的高出血风险患者中比伐卢定与普通肝素的随机对照比较。
JACC Cardiovasc Interv. 2015 Mar;8(3):414-423. doi: 10.1016/j.jcin.2014.10.015. Epub 2015 Feb 18.
6
Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial.普通肝素与比伐卢定在经皮冠状动脉介入治疗（HEAT-PPCI）中的应用：一项开放标签、单中心、随机对照试验。
Lancet. 2014 Nov 22;384(9957):1849-1858. doi: 10.1016/S0140-6736(14)60924-7. Epub 2014 Jul 4.
7
Bivalirudin started during emergency transport for primary PCI.比伐卢定在紧急转运行直接经皮冠状动脉介入治疗（PCI）期间开始使用。
N Engl J Med. 2013 Dec 5;369(23):2207-17. doi: 10.1056/NEJMoa1311096. Epub 2013 Oct 30.
8
2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.2013年美国心脏病学会基金会/美国心脏协会ST段抬高型心肌梗死管理指南：美国心脏病学会基金会/美国心脏协会实践指南工作组报告
J Am Coll Cardiol. 2013 Jan 29;61(4):e78-e140. doi: 10.1016/j.jacc.2012.11.019. Epub 2012 Dec 17.
9
Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial.高龄、抗栓策略与非ST段抬高型急性冠脉综合征的出血：急性导管插入与紧急干预分诊策略（ACUITY）试验结果
J Am Coll Cardiol. 2009 Mar 24;53(12):1021-30. doi: 10.1016/j.jacc.2008.12.021.
10
Development and validation of a prognostic risk score for major bleeding in patients undergoing percutaneous coronary intervention via the femoral approach.经股动脉途径行冠状动脉介入治疗患者大出血预后风险评分的建立与验证
Eur Heart J. 2007 Aug;28(16):1936-45. doi: 10.1093/eurheartj/ehm194. Epub 2007 Jun 15.