Liu Yongchun, Gao Wei, Zhang Chunhong, Tang Peng, Zhao Yuan, Wu Daocheng
Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
Chem Commun (Camb). 2017 Sep 26;53(77):10680-10683. doi: 10.1039/c7cc05783k.
We developed a novel sequential molecule-triggered-release system based on acetylated amylose helix aggregates with a proper degree of substitution, in which a loaded molecule can be trigger-released by trigger molecules in sequence. The system is sensitive and capable of time-controllable triggered release. The mechanism involves the sequential pushing of wrapped molecules with low binding free energy out of the helix cavity by a triggered molecule with a high binding free energy.
我们基于具有适当取代度的乙酰化直链淀粉螺旋聚集体开发了一种新型的顺序分子触发释放系统，其中负载的分子可以被触发分子依次触发释放。该系统灵敏且能够进行时间可控的触发释放。其机制涉及具有高结合自由能的触发分子将具有低结合自由能的包裹分子依次从螺旋腔中推出。
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