Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
J Med Virol. 2018 Feb;90(2):358-366. doi: 10.1002/jmv.24943. Epub 2017 Nov 7.
Aims of the study were to evaluate Human Papillomavirus (HPV) and type-specific prevalence in four anatomical sites in HIV infected men who have sex with men (MSM) compared with HIV uninfected MSM. Participants were recruited among the attendees of Infectious Diseases Clinics in Central Italy. A trained medical practitioner collected by interview sociodemographic data and information on medical history, sexual behavior, and drug use. Swabs from anal canal, oral cavity, urethral mucosa, and coronal sulcus were tested for HPV DNA and genotyping. Ninety MSM were enrolled, 45 subjects within each group. Overall, 48.9% MSM were HPV positive and prevalence was higher in HIV infected men (60.0% vs 37.8%, P = 0.035). HPV at multiple anatomic sites occurred in 59.1% MSM, with 34.1% and 22.7% at two and three sites, respectively. Prevalence of anal, coronal sulcus, oral, and urethral HPV was 96.3%, 37%, 21.6%, and 18.5% in HIV infected MSM, and 70.6%, 70.6%, 29.4%, and 23.5% among HIV uninfected. A similar proportion of HIV infected and uninfected MSM (59.2% and 58.8%) carried at least one high-risk genotype. Prevalence of types covered by nonavalent vaccine was 77.8% in HIV infected compared with 82.3% in HIV uninfected MSM. HPV 58 and 16 were mostly detected in HIV positive (43.7% and 31.2%) and negative MSM (50.0% and 40.0%). HPV detection rate underlined the high vulnerability of MSM to acquire multisite infections, characterized by various genotype combinations. Since nonavalent vaccine could have prevented 80% of HPV infections, study findings support the implementation of vaccination programs among MSM.
研究目的是评估在与未感染 HIV 的男男性行为者（MSM）相比，感染 HIV 的 MSM 中，在四个解剖部位的人乳头瘤病毒（HPV）和特定类型的流行率。参与者是在意大利中部传染病诊所的就诊者中招募的。一名经过培训的医务人员通过访谈收集社会人口统计学数据和病史、性行为和药物使用信息。从肛门、口腔、尿道黏膜和冠状沟采集拭子，检测 HPV DNA 和基因分型。共纳入 90 名 MSM，每组 45 名。总体而言，48.9%的 MSM 为 HPV 阳性，感染 HIV 的男性患病率更高（60.0%比 37.8%，P=0.035）。59.1%的 MSM 在多个解剖部位存在 HPV，其中 34.1%和 22.7%分别在两个和三个部位。感染 HIV 的 MSM 中，肛门、冠状沟、口腔和尿道 HPV 的患病率分别为 96.3%、37%、21.6%和 18.5%，未感染 HIV 的 MSM 中分别为 70.6%、70.6%、29.4%和 23.5%。感染 HIV 和未感染 HIV 的 MSM 携带至少一种高危基因型的比例相似（59.2%和 58.8%）。在感染 HIV 的 MSM 中，九价疫苗涵盖的 HPV 类型的患病率为 77.8%，而在未感染 HIV 的 MSM 中为 82.3%。HPV58 和 16 主要在 HIV 阳性（43.7%和 31.2%）和阴性 MSM（50.0%和 40.0%）中检出。HPV 检出率突出了 MSM 易发生多部位感染的高脆弱性，其特征是各种基因型组合。由于九价疫苗可以预防 80%的 HPV 感染，因此研究结果支持在 MSM 中实施疫苗接种计划。
