血浆肠碱性磷酸酶和中等分子量γ-谷氨酰转移酶活性在黄疸鉴别诊断中的应用
Plasma intestinal alkaline phosphatase and intermediate molecular mass gamma glutamyltransferase activities in the differential diagnosis of jaundice.
作者信息
Collins D, Goold M F, Rosalki S B, Mayne P D, Foo A Y
机构信息
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, London.
出版信息
J Clin Pathol. 1987 Oct;40(10):1252-5. doi: 10.1136/jcp.40.10.1252.
An assessment was made of the value of: (i) the demonstration of intestinal alkaline phosphatase in plasma for the differentiation of intrahepatic from post-hepatic jaundice in 122 jaundiced patients; and (ii) the demonstration of an intermediate molecular mass gamma glutamyltransferase in plasma for the identification of post-hepatic cholestasis in 74 jaundiced patients. The first test had a diagnostic sensitivity of only 32% with a specificity of 86%; the second test had a sensitivity of 50% and specificity of 75%. It is concluded that neither procedure is worth while.
对以下两项检测的价值进行了评估
（i）检测122例黄疸患者血浆中的肠碱性磷酸酶，以鉴别肝内黄疸和肝后性黄疸；（ii）检测74例黄疸患者血浆中的中等分子量γ-谷氨酰转移酶，以识别肝后性胆汁淤积。第一项检测的诊断敏感性仅为32%，特异性为86%；第二项检测的敏感性为50%，特异性为75%。结论是这两种方法都不值得采用。
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