Pastolero G C, Mori S
Department of Pathology, University of Tokyo, Japan.
Jpn J Exp Med. 1987 Jun;57(3):193-8.
40 specimens consisting of 27 carcinomas, 9 lymphomas, 2 thymomas, 1 sarcoma and 1 neurinoma were studied by immunoperoxidase technique to demonstrate a cell proliferation-associated antigen defined by proliferating cells (PC) antibody. Though PC antibody expression did not seem to correlate well with histologic grading of carcinomas, positivity to this was consistently more intense in carcinomas than in normal epithelia. Correlation with histologic grading of lymphomas was more significant: the high grade types, e.g. ATL, exhibited greater positivity than intermediate grade types, e.g. diffuse medium lymphoma and certainly much more than low grade types, e.g. follicular lymphomas. These data were compared to another proliferation-associated antigen, the transferrin receptor.
采用免疫过氧化物酶技术对40个标本进行研究，其中包括27例癌、9例淋巴瘤、2例胸腺瘤、1例肉瘤和1例神经鞘瘤，以显示由增殖细胞（PC）抗体定义的细胞增殖相关抗原。虽然PC抗体表达似乎与癌的组织学分级相关性不佳，但癌组织中该抗体的阳性表达始终比正常上皮组织更强。与淋巴瘤组织学分级的相关性更为显著：高级别类型，如成人T细胞白血病/淋巴瘤（ATL），比中级别类型，如弥漫性中等淋巴瘤，显示出更强的阳性表达，且肯定比低级别类型，如滤泡性淋巴瘤，阳性表达强得多。这些数据与另一种增殖相关抗原——转铁蛋白受体进行了比较。
