Tsuru H, Negita S
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
Jpn J Pharmacol. 1987 Aug;44(4):489-92. doi: 10.1254/jjp.44.489.
The buccal segment of the canine facial vein which was precontracted moderately with prostaglandin F2 alpha relaxed to different extents in response to dopamine (DA), norepinephrine (NE), epinephrine (Epi) and isoproterenol (Isp). Propranolol (10(-6) M) reversed the relaxation responses to contractions. In the presence of an alpha-adrenoceptor blockade and inhibitors of neuronal and extraneuronal uptakes, the four catecholamines relaxed the vein fully, and the order of pD2 values was Isp (8.34) greater than Epi (7.53) approximately equal to NE (7.50) much greater than DA (5.31). The results indicate that in the canine facial vein, beta-adrenoceptors predominate over alpha-adrenoceptors, and the subtype of beta-adrenoceptor may be the beta 1-type.
犬面静脉的颊段预先用前列腺素F2α适度预收缩后，对多巴胺（DA）、去甲肾上腺素（NE）、肾上腺素（Epi）和异丙肾上腺素（Isp）产生不同程度的舒张反应。普萘洛尔（10⁻⁶ M）使舒张反应逆转至收缩状态。在α-肾上腺素能受体阻断以及神经元和非神经元摄取抑制剂存在的情况下，四种儿茶酚胺使静脉完全舒张，pD2值的顺序为异丙肾上腺素（8.34）大于肾上腺素（7.53）约等于去甲肾上腺素（7.50）远大于多巴胺（5.31）。结果表明，在犬面静脉中，β-肾上腺素能受体比α-肾上腺素能受体占优势，且β-肾上腺素能受体亚型可能是β1型。
