Harousseau J L, Tobelem G, Schaison G, Jacquillat C
Nouv Presse Med. 1979 May 19;8(22):1827-30.
The frequency and the severity of disseminated intravascular coagulation (DIC) and of metabolic complications during the induction treatment were studied in 62 cases of acute lymphocytic leukemia with initial white blood cell count over 100 000/cu mm. Transient DIC were noted in 20,5% of cases. Metabolic complications were frequent: hyper-uricemia noted in 62% of cases was not the chief problem. Hyperazotemia was noted in 33% of cases and hyperkaliemia in 26% of cases. Hypocalcemia, noted in 34% of cases, was always associated with hyperphosphoremia. Blood glucose was low in 4 cases and increased in 7 cases out of 39.
对62例初发白细胞计数超过100000/立方毫米的急性淋巴细胞白血病患者在诱导治疗期间弥散性血管内凝血（DIC）和代谢并发症的发生率及严重程度进行了研究。20.5%的病例出现短暂性DIC。代谢并发症很常见：62%的病例出现高尿酸血症，但并非主要问题。33%的病例出现氮质血症，26%的病例出现高钾血症。34%的病例出现低钙血症，且总是伴有高磷血症。39例中有4例血糖降低，7例血糖升高。
