Merry A F, Gargiulo D A, Fry L E
Professor, Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland.
Anaesth Intensive Care. 2017 Sep;45(5):539-542. doi: 10.1177/0310057X1704500503.
In preparation for a case, an anaesthetist opened a 20 ml glass vial of propofol and aspirated the propofol into a syringe via a blunt drawing-up needle. Increased resistance was felt with aspiration. On inspection, a shard of glass was found at the tip of the drawing-up needle. The shard was presumed to be from the propofol ampoule, and to have fallen into the solution upon snapping open its glass tip. This illustrative case raises the issue of contamination of drugs by particles introduced during the drawing-up process. It also highlights the possibility that during the drawing-up process, intravenous drugs may become contaminated not just with particles, but with microorganisms on the surface of the particles. In this article, we discuss relevant recent research of the implications of this type of drug contamination. We draw attention to the need for meticulous care in drawing up and administering intravenous drugs during anaesthesia, particularly propofol.
在准备一个病例时，一名麻醉师打开了一瓶20毫升的丙泊酚玻璃小瓶，并通过钝头抽取针将丙泊酚吸入注射器。抽取时感觉阻力增加。检查发现，抽取针尖端有一块玻璃碎片。推测该碎片来自丙泊酚安瓿瓶，在打开其玻璃尖端时掉入溶液中。这个典型案例提出了在抽取过程中引入的颗粒污染药物的问题。它还凸显了在抽取过程中，静脉注射药物不仅可能被颗粒污染，还可能被颗粒表面的微生物污染的可能性。在本文中，我们讨论了关于这类药物污染影响的近期相关研究。我们提请注意在麻醉期间抽取和使用静脉注射药物，尤其是丙泊酚时需要格外小心。
