Sugiura Yasoo, Fujimoto Hiroyuki, Yamamoto Munehiro, Nomura Hisashi, Hashizume Toshinori, Kawai Osamu, Araki Norito, Kawakami Kotaro, Sueki Hitoshi, Fusegawa Hisae, Ohkubo Yasuyuki, Nemoto Etsuo
Dept. of Thoracic Surgery, National Hospital Organization, Kanagawa National Hospital.
Gan To Kagaku Ryoho. 2017 Sep;44(9):787-789.
Immune checkpoint-blocking antibodies may induce specific side effects known as immune-relatedad verse events.
A 66-year-oldman without any history of autoimmune disease was referredto our hospital for treatment of lung cancer in the right upper lobe. The tumor was diagnosed as Stage III A non-small-cell lung cancer by using bronchoscopic biopsy, computedtomography, andFDG -PET. After a single course of cisplatin andpemetrexed , the tumor size increasedremarkably andthe regimen was changedto nivolumab(3mg/kg every 2 weeks). Psoriasis andpsoriatic arthritis were observed after 4 courses of nivolumab. Nivolumab treatment continued, and the oral administration of predni- solone(20mg/day)couldimprove psoriasis andpsoriatic arthritis. However, the lung cancer showedprogressive disease after the 11th course of nivolumab.
Psoriasis andpsoriatic arthritis were inducedby nivolumab in the patient without any history of autoimmune disease. It is unclear how prednisolone affected nivolumab for the treatment of lung cancer.
免疫检查点阻断抗体可能会引发特定的副作用，即免疫相关不良反应。
一名66岁男性，无自身免疫性疾病病史，因右上叶肺癌被转诊至我院治疗。通过支气管镜活检、计算机断层扫描和氟代脱氧葡萄糖正电子发射断层扫描，该肿瘤被诊断为ⅢA期非小细胞肺癌。在接受一个疗程的顺铂和培美曲塞治疗后，肿瘤大小显著增加，治疗方案改为纳武单抗（每2周3mg/kg）。在使用纳武单抗4个疗程后，观察到银屑病和银屑病关节炎。继续使用纳武单抗治疗，口服泼尼松龙（20mg/天）可改善银屑病和银屑病关节炎。然而，在纳武单抗第11个疗程后，肺癌出现疾病进展。
纳武单抗在无自身免疫性疾病病史的患者中诱发了银屑病和银屑病关节炎。尚不清楚泼尼松龙对纳武单抗治疗肺癌有何影响。
