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受叉尾或非叉尾感染的小鼠肝脏和皮肤转录组图谱的比较研究

Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed .

作者信息

Yang Yan, He Jun-Jun, Hu Shuang, Chang Hua, Xiang Xun, Yang Jian-Fa, Zou Feng-Cai

机构信息

Key Laboratory of Veterinary Public Health of Yunnan Province, College of Veterinary Medicine, Yunnan Agricultural UniversityKunming, China.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesLanzhou, China.

出版信息

Front Microbiol. 2017 Aug 30;8:1648. doi: 10.3389/fmicb.2017.01648. eCollection 2017.

Abstract

() is a worldwide spread pathogen which penetrates host skin and then induces several diseases in infected host, such as fibrosis, formation of granulomas, hepatocirrhosis, and hepatomegaly. In present study, for the first time, transcriptomic profiles of mouse livers and skins infected by fork-tailed cercaria or non-fork-tailed cercaria were analyzed by using RNA-seq. The present findings demonstrated that transcriptomic landscapes of livers and skins infected by fork-tailed cercaria or non-fork-tailed cercaria were different. has great influence on hepatic metabolic processes. Fork-tailed cercaria upregulated hepatic metabolic processes, while non-fork-tailed cercaria downregulated hepatic metabolic processes. For the metabolism process or the metabolism enzyme expressional change, the pharmacokinetics of host could be changed during infection, regardless the biotypes of cercariae. The changes of infected skins focused on upregulation of immune response. During the skin infection period, fork-tailed cercaria infection induced stronger immune response comparing with that immune response triggered by non-fork-tailed cercaria. The transcription factor enrichment analysis showed that Irf7, Stat1 and Stat2 could play important roles in gene regulation during fork-tailed cercaria infection.

摘要

()是一种在全球范围内传播的病原体,它穿透宿主皮肤,然后在受感染的宿主体内引发多种疾病,如纤维化、肉芽肿形成、肝硬化和肝肿大。在本研究中,首次使用RNA测序分析了感染叉尾蚴或非叉尾蚴的小鼠肝脏和皮肤的转录组概况。目前的研究结果表明,感染叉尾蚴或非叉尾蚴的肝脏和皮肤的转录组图谱是不同的。()对肝脏代谢过程有很大影响。叉尾蚴上调肝脏代谢过程,而非叉尾蚴下调肝脏代谢过程。对于代谢过程或代谢酶表达变化,无论尾蚴的生物型如何,宿主在感染期间的药代动力学都可能发生变化。受感染皮肤的变化主要集中在免疫反应的上调。在皮肤感染期间,与非叉尾蚴引发的免疫反应相比,叉尾蚴感染诱导更强的免疫反应。转录因子富集分析表明,Irf7、Stat1和Stat2可能在叉尾蚴感染期间的基因调控中发挥重要作用。

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