韩国儿科患者中 基因和 基因多态性与自身免疫性甲状腺疾病的关联。
Association of Polymorphisms in and with Autoimmune Thyroid Disease in Korean Pediatric Patients.
作者信息
Cho Won Kyoung, Jang Jung-Pil, Choi Eun-Jeong, Ahn Moonbae, Kim Shin Hee, Cho Kyoung Soon, Park So Hyun, Baek In Cheol, Jung Min Ho, Kim Tai-Gyu, Suh Byung-Kyu
机构信息
Department of Pediatrics, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
Int J Endocrinol. 2017;2017:2304218. doi: 10.1155/2017/2304218. Epub 2017 Aug 20.
BACKGROUND
() have been suggested to be associated with the development of AITD.
METHODS
Fifteen single-nucleotide polymorphisms in 7 genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls.
RESULTS
GD showed higher frequencies of the C allele than control. TAO showed a lower frequency of the CT genotype and non-TAO showed a higher frequency of the CC genotype than control. The frequency of the CC genotype in TAO was higher than that in non-TAO. GD females showed a higher frequency of the 4 T allele, CC genotype, and the C allele than controls. GD males showed a higher frequency of the CC genotype and TT genotype and lower frequency of the CT genotype than control. The frequency of the CC genotype, C allele and TT genotype, and T allele in a GD female were lower than in a GD male.
CONCLUSIONS
Our results suggest that and polymorphisms might contribute to the pathogenesis of GD and TAO.
背景
（）已被认为与自身免疫性甲状腺疾病（AITD）的发生有关。
方法
对104名患有AITD的韩国儿童（女孩86名，男孩18名）（桥本氏病（HD）44名，格雷夫斯病（GD）60名，甲状腺相关眼病（TAO）29名，非TAO 31名）以及183名对照者分析了7个基因中的15个单核苷酸多态性。
结果
GD患者中C等位基因的频率高于对照组。TAO患者中CT基因型的频率低于对照组，非TAO患者中CC基因型的频率高于对照组。TAO患者中CC基因型的频率高于非TAO患者。GD女性患者中4个T等位基因、CC基因型和C等位基因的频率高于对照组。GD男性患者中CC基因型和TT基因型的频率高于对照组，CT基因型的频率低于对照组。GD女性患者中CC基因型、C等位基因以及TT基因型和T等位基因的频率低于GD男性患者。
结论
我们的结果表明，（）多态性可能与GD和TAO的发病机制有关。
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