Zhang Chunlin, Yang Zhiping, Luo Ping, Ye Mengxia, Gong Ping, Gong Quan, Mei Bing
Department of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, 434000, China.
Department of Pathology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, 434000, China.
Biomark Med. 2023 Feb;17(3):133-142. doi: 10.2217/bmm-2022-0702. Epub 2023 Apr 25.
Toll-like receptors involved in tumor-associated inflammatory response, this study aimed to investigate the role of and gene polymorphisms in the risk and progression of HPV-related cervical lesions. A total of 220 cervical lesion patients and 227 healthy controls were enrolled. Single-nucleotide polymorphisms were genotyped using PCR-restriction fragment length polymorphism. A significantly decreased risk of cervical lesions was observed to be associated with the rs10116253 (C), rs1927911 (T) and rs10759931 (G) mutant alleles. rs187084-rs1927911-HPV-16/18 was the best interaction model to affect cervical lesion risk. rs10116253, rs1927911 and rs10759931 were potential biomarkers for cervical lesion susceptibility.
Toll样受体参与肿瘤相关炎症反应，本研究旨在探讨 和 基因多态性在人乳头瘤病毒（HPV）相关宫颈病变的风险及进展中的作用。共纳入220例宫颈病变患者和227例健康对照。采用聚合酶链反应-限制性片段长度多态性方法对单核苷酸多态性进行基因分型。观察到宫颈病变风险显著降低与Toll样受体 rs101,16253（C）、rs192,7911（T）和rs107,59931（G）突变等位基因相关。rs187084-rs1927911-HPV-16/18是影响宫颈病变风险的最佳相互作用模型。rs10116253、rs1927911和rs10759931是宫颈病变易感性的潜在生物标志物。
