Association of and gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.

Toll-like receptors involved in tumor-associated inflammatory response, this study aimed to investigate the role of and gene polymorphisms in the risk and progression of HPV-related cervical lesions. A total of 220 cervical lesion patients and 227 healthy controls were enrolled. Single-nucleotide polymorphisms were genotyped using PCR-restriction fragment length polymorphism. A significantly decreased risk of cervical lesions was observed to be associated with the rs10116253 (C), rs1927911 (T) and rs10759931 (G) mutant alleles. rs187084-rs1927911-HPV-16/18 was the best interaction model to affect cervical lesion risk. rs10116253, rs1927911 and rs10759931 were potential biomarkers for cervical lesion susceptibility.