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强力霉素诱发的急性胰腺炎:一种罕见的不良事件。

Doxycycline-Induced Acute Pancreatitis: A Rare Adverse Event.

作者信息

Rawla Prashanth, Raj Jeffrey Pradeep

机构信息

Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA.

Department of Pharmacology, St John's Medical College, Bangalore, India.

出版信息

Gastroenterology Res. 2017 Aug;10(4):244-246. doi: 10.14740/gr838w. Epub 2017 Aug 31.

Abstract

Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized.

摘要

多西环素是一种属于四环素类的广谱抗生素,其作用机制是抑制细菌蛋白质合成。它被认为是一种相对安全的药物。我们报告了一例成年女性患者发生多西环素诱导的急性胰腺炎(DIAP)的病例,该患者在1周前因寻常痤疮开始使用常规治疗剂量。世界卫生组织因果关系评估是可行的,Naranjo量表将其确认为“肯定”的药物不良反应。本文还总结了先前报道DIAP的病例报告的简要文献综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d71/5593444/1c103a493408/gr-10-244-g001.jpg

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