Rawla Prashanth, Raj Jeffrey Pradeep
Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA.
Department of Pharmacology, St John's Medical College, Bangalore, India.
Gastroenterology Res. 2017 Aug;10(4):244-246. doi: 10.14740/gr838w. Epub 2017 Aug 31.
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized.
多西环素是一种属于四环素类的广谱抗生素,其作用机制是抑制细菌蛋白质合成。它被认为是一种相对安全的药物。我们报告了一例成年女性患者发生多西环素诱导的急性胰腺炎(DIAP)的病例,该患者在1周前因寻常痤疮开始使用常规治疗剂量。世界卫生组织因果关系评估是可行的,Naranjo量表将其确认为“肯定”的药物不良反应。本文还总结了先前报道DIAP的病例报告的简要文献综述。