Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China.
Zhejiang Provincial Key Laboratory of Drug Evaluation and Clinical Research, Hangzhou, China.
BMC Infect Dis. 2024 Sep 30;24(1):1072. doi: 10.1186/s12879-024-09983-w.
Omadacycline is a new generation of tetracycline antibiotics, and its clinical application is increasing. We report the first case of acute pancreatitis possibly induced by omadacycline.
The patient was admitted to the emergency intensive care unit due to community-acquired pneumonia. The initial treatment consisted of meropenem combined with levofloxacin, and the regimen was subsequently switched to omadacycline combined with cefoperazone/sulbactam due to sputum culture showing carbapenem-resistant Acinetobacter baumannii. Seven days after the administration of omadacycline, abdominal tenderness occurred, and CT scan revealed an enlarged gallbladder with exudation from the pancreatic head. The patient was diagnosed with acute pancreatitis and improved after dis-continuing omadacycline.
Omadacycline, like other tetracycline antibiotics, may cause pancreatitis. Combination medications can be an important factor in this adverse reaction.
奥马环素是新一代四环素类抗生素，其临床应用日益增多。我们报告了首例可能由奥马环素引起的急性胰腺炎。
患者因社区获得性肺炎入住急诊重症监护病房。初始治疗采用美罗培南联合左氧氟沙星，随后由于痰培养显示耐碳青霉烯鲍曼不动杆菌，方案改为奥马环素联合头孢哌酮/舒巴坦。奥马环素治疗 7 天后出现腹痛，CT 扫描显示胆囊增大，胰头部渗出。患者被诊断为急性胰腺炎，停用奥马环素后病情好转。
奥马环素与其他四环素类抗生素一样，可能引起胰腺炎。联合用药可能是这种不良反应的一个重要因素。
