在人软骨细胞中，TRPA1表达受地塞米松和金硫代苹果酸下调：TRPA1作为关节炎中的一个新因子和药物靶点。 - Suppr

TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

作者信息

Nummenmaa Elina, Hämäläinen Mari, Moilanen Lauri J, Moilanen Teemu, Vuolteenaho Katriina, Moilanen Eeva

机构信息

The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland.

Coxa Hospital for Joint Replacement, Tampere, Finland.

出版信息

RMD Open. 2017 Sep 4;3(2):e000556. doi: 10.1136/rmdopen-2017-000556. eCollection 2017.

DOI:10.1136/rmdopen-2017-000556

PMID:28912961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5588971/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b0/5588971/0c7ba61ca589/rmdopen-2017-000556f01.jpg

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TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

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Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes.

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Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilage.

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Effects of dexamethasone on proteoglycan content and gene expression of IL-1beta-stimulated osteoarthrotic chondrocytes in vitro.

Acta Orthop Scand. 2002 Oct;73(5):562-7. doi: 10.1080/000164702321022857.

Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids.

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Expression patterns of neurotrophins and neurotrophin receptors in articular chondrocytes and inflammatory infiltrates in knee joint arthritis.

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本文引用的文献

Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes.

Arthritis Res Ther. 2016 Aug 11;18(1):185. doi: 10.1186/s13075-016-1080-4.

Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

Physiol Rev. 2016 Apr;96(2):409-47. doi: 10.1152/physrev.00011.2015.

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

Osteoarthritis Cartilage. 2015 Nov;23(11):2017-26. doi: 10.1016/j.joca.2015.09.008.

TRPA1.

Handb Exp Pharmacol. 2014;222:583-630. doi: 10.1007/978-3-642-54215-2_23.

TRPA1: a transducer and amplifier of pain and inflammation.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):50-5. doi: 10.1111/bcpt.12138. Epub 2013 Oct 7.

TRPA1: A gatekeeper for inflammation.

Annu Rev Physiol. 2013;75:181-200. doi: 10.1146/annurev-physiol-030212-183811. Epub 2012 Sep 27.

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.

J Biol Chem. 2012 Sep 14;287(38):31962-72. doi: 10.1074/jbc.M112.361139. Epub 2012 Jul 26.

Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilage.

Scand J Rheumatol. 2005 Nov-Dec;34(6):475-9. doi: 10.1080/03009740510026797.

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.

J Clin Invest. 1994 Dec;94(6):2307-16. doi: 10.1172/JCI117595.

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TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

作者信息

Nummenmaa Elina, Hämäläinen Mari, Moilanen Lauri J, Moilanen Teemu, Vuolteenaho Katriina, Moilanen Eeva

机构信息

The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland.

Coxa Hospital for Joint Replacement, Tampere, Finland.

出版信息

RMD Open. 2017 Sep 4;3(2):e000556. doi: 10.1136/rmdopen-2017-000556. eCollection 2017.

DOI:10.1136/rmdopen-2017-000556

PMID:28912961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5588971/

Abstract

摘要

相似文献

TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

RMD Open. 2017 Sep 4;3(2):e000556. doi: 10.1136/rmdopen-2017-000556. eCollection 2017.

Arthritis Rheum. 2010 Jun;62(6):1650-9. doi: 10.1002/art.27409.

Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes.

Scand J Rheumatol. 2015;44(1):74-9. doi: 10.3109/03009742.2014.927917. Epub 2014 Oct 14.

Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability.

Eur J Pharmacol. 2008 Jun 10;587(1-3):309-16. doi: 10.1016/j.ejphar.2008.03.016. Epub 2008 Mar 29.

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

Osteoarthritis Cartilage. 2015 Nov;23(11):2017-26. doi: 10.1016/j.joca.2015.09.008.

Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilage.

Scand J Rheumatol. 2005 Nov-Dec;34(6):475-9. doi: 10.1080/03009740510026797.

Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice.

Arthritis Res Ther. 2016 Jan 8;18:6. doi: 10.1186/s13075-015-0904-y.

Effects of dexamethasone on proteoglycan content and gene expression of IL-1beta-stimulated osteoarthrotic chondrocytes in vitro.

Acta Orthop Scand. 2002 Oct;73(5):562-7. doi: 10.1080/000164702321022857.

Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids.

Am J Vet Res. 1996 Nov;57(11):1631-4.

Expression patterns of neurotrophins and neurotrophin receptors in articular chondrocytes and inflammatory infiltrates in knee joint arthritis.

Cells Tissues Organs. 2008;188(3):299-309. doi: 10.1159/000121432. Epub 2008 Mar 19.

引用本文的文献

The Potential of TRPA1 as a Therapeutic Target in Cancer-A Study Using Bioinformatic Tools.

Pharmaceuticals (Basel). 2024 Dec 9;17(12):1657. doi: 10.3390/ph17121657.

Potentiating TRPA1 by Sea Anemone Peptide Ms 9a-1 Reduces Pain and Inflammation in a Model of Osteoarthritis.

Mar Drugs. 2023 Nov 28;21(12):617. doi: 10.3390/md21120617.

The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells.

Inflamm Res. 2023 Jul;72(7):1327-1339. doi: 10.1007/s00011-023-01750-y. Epub 2023 Jun 29.

Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets.

Int J Mol Sci. 2023 Jun 13;24(12):10057. doi: 10.3390/ijms241210057.

Analgesic Mechanisms of Steroid Ointment against Oral Ulcerative Mucositis in a Rat Model.

Int J Mol Sci. 2021 Nov 22;22(22):12600. doi: 10.3390/ijms222212600.

Transient Receptor Potential Ankyrin 1 (TRPA1)-An Inflammation-Induced Factor in Human HaCaT Keratinocytes.

Int J Mol Sci. 2021 Mar 24;22(7):3322. doi: 10.3390/ijms22073322.

Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models.

Int J Mol Sci. 2020 Dec 23;22(1):87. doi: 10.3390/ijms22010087.

本文引用的文献

Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes.

Arthritis Res Ther. 2016 Aug 11;18(1):185. doi: 10.1186/s13075-016-1080-4.

Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

Physiol Rev. 2016 Apr;96(2):409-47. doi: 10.1152/physrev.00011.2015.

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

Osteoarthritis Cartilage. 2015 Nov;23(11):2017-26. doi: 10.1016/j.joca.2015.09.008.

TRPA1.

Handb Exp Pharmacol. 2014;222:583-630. doi: 10.1007/978-3-642-54215-2_23.

TRPA1: a transducer and amplifier of pain and inflammation.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):50-5. doi: 10.1111/bcpt.12138. Epub 2013 Oct 7.

TRPA1: A gatekeeper for inflammation.

Annu Rev Physiol. 2013;75:181-200. doi: 10.1146/annurev-physiol-030212-183811. Epub 2012 Sep 27.

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.

J Biol Chem. 2012 Sep 14;287(38):31962-72. doi: 10.1074/jbc.M112.361139. Epub 2012 Jul 26.

Aurothiomalate and hydroxychloroquine inhibit nitric oxide production in chondrocytes and in human osteoarthritic cartilage.

Scand J Rheumatol. 2005 Nov-Dec;34(6):475-9. doi: 10.1080/03009740510026797.

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.

J Clin Invest. 1994 Dec;94(6):2307-16. doi: 10.1172/JCI117595.

TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

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TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis.

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