Sever Erman, Doğer Emek, Çakıroğlu Yiğit, Sünnetçi Deniz, Çine Naci, Savlı Hakan, Yücesoy İzzet
Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, Kocaeli, Turkey.
Kocaeli University Faculty of Medicine, Department of Medical Genetics, Kocaeli, Turkey.
Turk J Obstet Gynecol. 2014 Dec;11(4):207-210. doi: 10.4274/tjod.05617. Epub 2014 Dec 15.
The aim of this study is to investigate the effect of first chromosome long arm duplication (dup(1q)) in cases with endometrial carcinoma detected with array based comperative genomic hybridization (aCGH) on survival from the cancer.
A total of 53 patients with the diagnosis of endometrial carcinom due to endometrial biopsy and who have been operated for this reason have been allocated in the study. Frozen section biopsy and staging surgery have been performed for all the cases. Samples obtained from the tumoral mass have been investigated for chromosomal aberrations with aCGH method. Kaplan-Meier and Cox-regression analysis have been performed for survival analysis.
Among 53 cases with endometrial carcinomas, dup(1q) was diagnosed in 14 (26.4%) of the cases. For the patient group that has been followed-up for 24 months (3-33 months), dup(1q) (p=.01), optimal cytoreduction (p<.001), lymph node positivity (p=.006), tumor stage >1 (p=.006) and presence of high risk tumor were the factors that were associated with survival. Cox-regression analysis has revealed that optimal cytoreduction was the most important prognostic factor (p=.02).
Presence of 1q duplication can be used as a prognostic factor in the preoperative period.
本研究旨在探讨采用基于芯片的比较基因组杂交技术（aCGH）检测出的子宫内膜癌患者中1号染色体长臂重复（dup(1q)）对癌症生存的影响。
本研究共纳入53例经子宫内膜活检诊断为子宫内膜癌并因此接受手术的患者。所有病例均进行了冰冻切片活检和分期手术。采用aCGH方法对肿瘤组织样本进行染色体畸变检测。采用Kaplan-Meier法和Cox回归分析进行生存分析。
53例子宫内膜癌患者中，14例（26.4%）诊断为dup(1q)。在随访24个月（3 - 33个月）的患者组中，dup(1q)（p = 0.01）、最佳细胞减灭术（p < 0.001）、淋巴结阳性（p = 0.006）、肿瘤分期>1（p = 0.006）以及存在高危肿瘤是与生存相关的因素。Cox回归分析显示最佳细胞减灭术是最重要的预后因素（p = 0.02）。
1q重复的存在可作为术前的一个预后因素。
