表达松弛素的腺病毒对瘢痕重塑的影响：一项初步研究。
Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study.
作者信息
Jung Bok Ki, Lee Won Jai, Kang Eunhye, Ahn Hyo Min, Kim Yong Oock, Rah Dong Kyun, Yun Chae-Ok, Yun In Sik
机构信息
Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Arch Craniofac Surg. 2017 Mar;18(1):9-15. doi: 10.7181/acfs.2017.18.1.9. Epub 2017 Mar 25.
BACKGROUND
Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.
METHODS
Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.
RESULTS
Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.
CONCLUSION
Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
背景
松弛素是一种转化生长因子β1拮抗剂。为了确定松弛素对减少瘢痕的作用，我们使用猪瘢痕模型通过注射表达松弛素的腺病毒来研究瘢痕重塑过程。
方法
在约克夏猪的背部制造全层瘢痕。瘢痕分为两组（松弛素组[RLX]和对照组）。将腺病毒分别注射到RLX组（表达松弛素）和对照组（不表达松弛素）。比较瘢痕表面积、颜色指数和柔韧性的变化。
结果
治疗50天后，RLX组瘢痕表面积减小，瘢痕颜色恢复正常，瘢痕柔韧性增加。
结论
表达松弛素的腺病毒改善了瘢痕的表面积、颜色和柔韧性。对瘢痕形成的治疗作用机制应进一步研究。
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