Departamento de Fisiología, Facultad Ciencias Biológicas, Pontificia Universidad Católica de Chile, 7820436 Santiago, Chile.
Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Químicas y Farmacéuticas & Facultad de Medicina, 8380494 Santiago, Chile.
Biomed Res Int. 2017;2017:4367019. doi: 10.1155/2017/4367019. Epub 2017 Aug 23.
The primary cilium is a nonmotile organelle that emanates from the surface of multiple cell types and receives signals from the environment to regulate intracellular signaling pathways. The presence of cilia, as well as their length, is important for proper cell function; shortened, elongated, or absent cilia are associated with pathological conditions. Interestingly, it has recently been shown that the molecular machinery involved in autophagy, the process of recycling of intracellular material to maintain cellular and tissue homeostasis, participates in ciliogenesis. Cilium-dependent signaling is necessary for autophagosome formation and, conversely, autophagy regulates both ciliogenesis and cilium length by degrading specific ciliary proteins. Here, we will discuss the relationship that exists between the two processes at the cellular and molecular level, highlighting what is known about the effects of ciliary dysfunction in the control of energy homeostasis in some ciliopathies.
纤毛是一种非运动细胞器，从多种细胞类型的表面伸出，接收来自环境的信号，以调节细胞内信号通路。纤毛的存在及其长度对于细胞的正常功能很重要；纤毛缩短、延长或缺失与病理状况有关。有趣的是，最近的研究表明，参与自噬的分子机制——回收细胞内物质以维持细胞和组织内稳态的过程——参与了纤毛发生。纤毛依赖性信号对于自噬体的形成是必需的，相反，自噬通过降解特定的纤毛蛋白来调节纤毛发生和纤毛长度。在这里，我们将讨论这两个过程在细胞和分子水平上的关系，重点介绍已知的纤毛功能障碍对某些纤毛病中能量稳态控制的影响。
