深度麻醉期间皮质连接性的变化。
Changes of cortical connectivity during deep anaesthesia.
作者信息
Pavel Bogdan, Acatrinei Camelia Alexandra, Menardy Fabien, Zahiu Carmen Mihaela Denise, Popa Daniela, Zagrean Ana-Maria, Zagrean Leon
机构信息
"Carol Davila" University of Medicine and Pharmacy, Division of Physiology and Fundamental Neurosciences, Bucharest, Romania.
Institut de Biologie de l'Ecole Normale Supérieure, Paris, France.
出版信息
Rom J Anaesth Intensive Care. 2015 Oct;22(2):83-88.
BACKGROUND AND AIMS
The aim of this study was to evaluate the frontal intracortical connectivity during deep anaesthesia (burst-suppression).
METHODS
Experiments were carried out on 5 adult Sprague Dawley rats. The anaesthesia was induced and maintained with isoflurane. Following the induction of anaesthesia, rats were placed in a stereotactic instrument. A hole was drilled in the skull over the frontal cortex and electrodes were inserted in order to record the local field potentials. Rats were maintained in deep level anaesthesia (burst-suppression). The cortical connectivity was assessed by computing the coherence spectra. The frontal intracortical connectivity was calculated during burst, suppression (non-burst) and slow wave anaesthesia periods.
RESULTS
The global cortical connectivity (0.5-100 Hz) was 0.61 ± 0.078 during the burst periods compared to 0.55 ± 0.032 (p < 0.05) during the suppression periods and 0.55 ± 0.015 (p < 0.05) during slow wave anaesthesia.
CONCLUSIONS
The global cortical connectivity increased during the burst periods compared to the suppression periods and slow wave anaesthesia. This increase in the cortical synchronization might be due to the subcortical origin of the bursts.
背景与目的
本研究旨在评估深度麻醉（爆发抑制）期间额叶皮质内的连接性。
方法
对5只成年Sprague Dawley大鼠进行实验。用异氟烷诱导并维持麻醉。麻醉诱导后，将大鼠置于立体定位仪中。在额叶皮质上方的颅骨上钻一个孔，并插入电极以记录局部场电位。使大鼠维持在深度麻醉（爆发抑制）状态。通过计算相干谱来评估皮质连接性。在爆发期、抑制期（非爆发期）和慢波麻醉期计算额叶皮质内连接性。
结果
爆发期的整体皮质连接性（0.5 - 100 Hz）为0.61±0.078，而抑制期为0.55±0.032（p < 0.05），慢波麻醉期为0.55±0.015（p < 0.05）。
结论
与抑制期和慢波麻醉相比，爆发期的整体皮质连接性增加。皮质同步性的这种增加可能归因于爆发的皮质下起源。
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