Mazidi Mohsen, Toth Peter P, Banach Maciej
1 Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
2 Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing, China.
Angiology. 2018 May;69(5):438-442. doi: 10.1177/0003319717729288. Epub 2017 Sep 15.
The prevalence of metabolic syndrome (MetS) has increased globally and is associated with an increased risk of cardiovascular diseases that may be related to its association with inflammation. We have assessed whether the prevalence of the MetS correlates with a serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of US men and women. Participants were selected from the US National Health and Nutrition Examination Survey from 2005 to 2010. Of the 17 689 participants analyzed, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample (between men and women P = .047). The prevalence of MetS, diabetes mellitus, and hypertension increased across quartiles for hsCRP (all P < .001). Moreover, we found that for the age-, race-, sex-, and smoking-adjusted logistic regression, with increasing hsCRP, the risk of having MetS increased with an odds ratio of 5.20 (95% confidence interval, 4.54-5.93, P < .001) when comparing the highest quartile of serum hsCRP with the lowest. This study provides further evidence for an association between MetS and subclinical inflammation.
代谢综合征(MetS)在全球范围内的患病率呈上升趋势,且与心血管疾病风险增加相关,这可能与其与炎症的关联有关。我们评估了在美国基于人群的男性和女性样本中,代谢综合征的患病率是否与血清高敏C反应蛋白(hsCRP)浓度相关。参与者选自2005年至2010年的美国国家健康和营养检查调查。在分析的17689名参与者中,8607名(48.3%)为男性。总体样本的平均年龄为45.8岁(男性和女性之间P = 0.047)。hsCRP四分位数范围内,代谢综合征、糖尿病和高血压的患病率均增加(所有P < 0.001)。此外,我们发现,对于年龄、种族、性别和吸烟调整后的逻辑回归分析,血清hsCRP最高四分位数与最低四分位数相比,随着hsCRP升高,患代谢综合征的风险增加,优势比为5.20(95%置信区间,4.54 - 5.93,P < 0.001)。本研究为代谢综合征与亚临床炎症之间的关联提供了进一步证据。