Department of Public Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
Nutrients. 2023 Mar 23;15(7):1560. doi: 10.3390/nu15071560.
Depression is a profound public health concern, yet its etiology remains unclear. A body's magnesium status and low-grade systemic inflammation are associated with depression. However, the interaction of magnesium status and inflammation on depression/depressive symptoms is unknown. We assessed the association between serum magnesium levels and depressive symptoms by analyzing data from the Nutrition and Health Survey in Taiwan 2005-2008. In total, 2196 participants aged ≥20 years were included. Depressive symptoms were assessed using the 5-item Brief-Symptom Rating Scale. We performed logistic regression and multiple linear regression analyses to examine the association. A dose-response analysis was performed using restricted cubic spline models, and stratification by chronic inflammation was also performed. We found that higher serum magnesium levels were associated with lower depression scores and a lower risk of depression. In the subgroup analysis, serum magnesium levels were inversely associated with depressive symptoms more prominently among people with higher CRP levels, with a threshold at 5 mg/L (≥5 vs. <5) showing a greater difference than at 3 mg/L (≥3 vs. <3). Conclusions: Serum magnesium levels were inversely associated with depressive symptoms. This inverse association was affected by inflammation level. A dose-response relationship was also observed.
抑郁症是一个严重的公共卫生问题，但它的病因仍不清楚。一个人的镁状态和低度系统性炎症与抑郁症有关。然而，镁状态和炎症对抑郁症/抑郁症状的相互作用尚不清楚。我们通过分析 2005-2008 年台湾营养与健康调查的数据，评估了血清镁水平与抑郁症状之间的关系。共有 2196 名年龄≥20 岁的参与者被纳入研究。抑郁症状采用 5 项简短症状评定量表进行评估。我们进行了逻辑回归和多元线性回归分析来检验这种关联。采用限制性立方样条模型进行了剂量反应分析，并进行了慢性炎症的分层分析。我们发现，较高的血清镁水平与较低的抑郁评分和较低的抑郁风险相关。在亚组分析中，在 CRP 水平较高的人群中，血清镁水平与抑郁症状呈负相关，在 5mg/L（≥5 与<5）时的差异比在 3mg/L（≥3 与<3）时更显著。结论：血清镁水平与抑郁症状呈负相关。这种负相关受炎症水平的影响。还观察到剂量反应关系。
