LaMontagne Erica D, Heese Antje
University of Missouri, Div. of Biochemistry, Interdisciplinary Plant Group (IPG), Columbia, MO, USA.
University of Missouri, Div. of Biochemistry, Interdisciplinary Plant Group (IPG), Columbia, MO, USA.
Curr Opin Plant Biol. 2017 Dec;40:114-121. doi: 10.1016/j.pbi.2017.08.012. Epub 2017 Sep 13.
In plants, the trans-Golgi network (TGN) functionally overlaps with the early endosome (EE), serving as a central sorting hub to direct newly synthesized and endocytosed cargo to the cell surface or vacuole. Here, we focus on the emerging role of the TGN/EE in sorting of immune cargo proteins for effective plant immunity against pathogenic bacteria and fungi. Specific vesicle coat and regulatory components at the TGN/EE ensure that immune cargoes are correctly sorted and transported to the location of their cellular functions. Our understanding of the identity of immune cargoes and the underlying cellular mechanisms regulating their sorting are still rudimentary, but this knowledge is essential to understanding the physiological contribution of the TGN/EE to effective immune responses.
在植物中，反式高尔基体网络（TGN）在功能上与早期内体（EE）重叠，作为一个核心分选枢纽，将新合成的和内吞的货物导向细胞表面或液泡。在这里，我们关注TGN/EE在分选免疫货物蛋白以实现植物对病原菌和真菌的有效免疫方面的新作用。TGN/EE处特定的囊泡包被和调节成分确保免疫货物被正确分选并运输到其细胞功能所在位置。我们对免疫货物的身份以及调节其分选的潜在细胞机制的理解仍然很初步，但这些知识对于理解TGN/EE对有效免疫反应的生理贡献至关重要。
