成人中叶酸代谢基因多态性与脑膜瘤和神经胶质瘤易感性
Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults.
作者信息
Chen Dongming, Dong Jun, Huang Ying, Gao Feng, Yang Xiaopeng, Gong Xianglun, Lv Xiaochen, Chu Chenghao, Wu Yonggang, Zheng Yong
机构信息
Neurosurgery Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang, China.
Respiratory Department, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang, China.
出版信息
Oncotarget. 2017 Jul 4;8(34):57265-57277. doi: 10.18632/oncotarget.18986. eCollection 2017 Aug 22.
Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies available to evaluate the relationship between folate metabolism genetic polymorphisms and the susceptibility to meningioma and glioma in adults. We searched the literature in PubMed, EMBASE and Cochrane Central Library for relevant articles published up to August 2016. The odds ratios (ORs) and the corresponding 95% confidence intervals (95%Cls) were used to evaluate the associations of two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) with the risk of meningioma and glioma in adults. We found significant association of MTHFR A1298C (rs1801131) variant genotypes with increased incidence of meningioma and glioma in this study population (CA vs. AA: OR=1.22, P<0.001; CA+CC vs. AA: OR=1.18, P=0.002). Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meningioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023). In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
参与叶酸代谢的基因多态性与脑膜瘤和胶质瘤的易感性有关，但已发表文章的结果存在争议且尚无定论。因此，我们进行了这项荟萃分析，纳入所有可得研究，以评估叶酸代谢基因多态性与成人脑膜瘤和胶质瘤易感性之间的关系。我们检索了截至2016年8月在PubMed、EMBASE和Cochrane中心图书馆发表的相关文献。采用比值比（OR）和相应的95%置信区间（95%Cl）来评估两种叶酸代谢基因变异MTRR A66G（rs1801394）和MTHFR A1298C（rs1801131）与成人脑膜瘤和胶质瘤风险的关联。我们发现，在本研究人群中，MTHFR A1298C（rs1801131）变异基因型与脑膜瘤和胶质瘤发病率增加显著相关（CA与AA相比：OR = 1.22，P < 0.001；CA + CC与AA相比：OR = 1.18，P = 0.002）。此外，我们发现MTRR A66G（rs1801394）变异基因型与脑膜瘤和胶质瘤风险增加有关（G与A相比：OR = 1.11，P = 0.020；GG与AA + AG相比：OR = 1.17，P = 0.043；GG与AA相比：OR = 1.22，P = 0.023）。总之，我们的荟萃分析表明，两种叶酸代谢基因变异MTRR A66G（rs1801394）和MTHFR A1298C（rs1801131）导致成人脑膜瘤和胶质瘤的遗传易感性。
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