J Neurooncol. 2013 Nov;115(2):233-9. doi: 10.1007/s11060-013-1218-z.
The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. A population-based case–control study involving 600 meningioma patients (World Health Organization [WHO] Grade I, 391 cases; WHO Grade II, 167 cases; WHO Grade III, 42 cases) and 600 controls was done for the MTHFR C677T and A1298C, MTRR A66G, and MTR A2756G variants in Chinese Han population. The folate metabolism gene polymorphisms were determined by using a polymerase chain reaction–restriction fragment length polymorphism assay. Meningioma cases had a significantly lower frequency of MTHFR 677 TT genotype [odds ratio (OR) = 0.49, 95 % confidence interval (CI) 0.33–0.74; P = 0.001] and T allele (OR = 0.80, 95 % CI 0.67–0.95; P = 0.01) than controls. A significant association between risk of meningioma and MTRR 66 GG (OR = 1.41, 95 % CI 1.02–1.96; P = 0.04) was also observed. When stratifying by the WHO grade of meningioma, no association was found. Our study suggested that MTHFR C677T and MTRR A66G variants may affect the risk of adult meningioma in Chinese Han population.
脑膜瘤的病因尚不清楚。叶酸代谢基因多态性与多种人类癌症有关。5,10-亚甲基四氢叶酸还原酶（MTHFR）、蛋氨酸合成酶（MTR）和蛋氨酸合成酶还原酶（MTRR）的叶酸代谢基因功能多态性与成人脑膜瘤的风险之间的关系仍然存在争议和模糊。一项基于人群的病例对照研究纳入了 600 例脑膜瘤患者（世界卫生组织[WHO]I 级 391 例，II 级 167 例，III 级 42 例）和 600 例对照，研究了中国汉族人群中 MTHFR C677T 和 A1298C、MTRR A66G 和 MTR A2756G 变体。采用聚合酶链反应-限制性片段长度多态性分析检测叶酸代谢基因多态性。脑膜瘤病例 MTHFR 677 TT 基因型的频率明显较低[比值比（OR）=0.49，95%置信区间（CI）0.33-0.74；P=0.001]，T 等位基因的频率也较低（OR=0.80，95%CI 0.67-0.95；P=0.01）。MTRR 66 GG 基因型与脑膜瘤风险之间也存在显著相关性（OR=1.41，95%CI 1.02-1.96；P=0.04）。当按脑膜瘤的 WHO 分级分层时，未发现相关性。本研究表明，MTHFR C677T 和 MTRR A66G 变体可能影响中国汉族人群成人脑膜瘤的风险。
