Lenz H J, Struck T, Greten H
Medizinische Kernklinik und Poliklinik, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Federal Republic of Germany.
Gastroenterology. 1988 Jan;94(1):103-8. doi: 10.1016/0016-5085(88)90616-6.
To determine the interactions of phenylalanine and tryptophan with gastric secretagogues, acid secretory studies were performed in 10 healthy subjects. Phenylalanine and tryptophan potentiated the gastric secretory responses following low doses of pentagastrin, whereas their effects on acid secretion stimulated by low doses of histamine or the cholinergic bethanecol were additive. Phenylalanine and tryptophan did not increase maximal acid output stimulated by pentagastrin, histamine, or bethanecol. Doses of the H2-receptor antagonist ranitidine, the prostaglandin E1 analogue misoprostol, atropine, and somatostatin that produced approximately 50% inhibition of pentagastrin-stimulated acid secretion significantly inhibited phenylalanine- and tryptophan-stimulated acid secretion. After the combination of either phenylalanine or tryptophan with pentagastrin, the H2-receptor antagonist significantly inhibited gastric acid secretion, whereas somatostatin, atropine, and the prostaglandin E1 analogue were not effective. These results indicate that both phenylalanine and tryptophan potentiate gastric acid secretion stimulated by a submaximal dose of pentagastrin, whereas their effects on histamine- and bethanecol-stimulated secretion are additive. The potentiating effects of phenylalanine and tryptophan on pentagastrin-stimulated acid secretion depend, at least in part, on intact histamine pathways.
为了确定苯丙氨酸和色氨酸与胃促分泌素的相互作用，对10名健康受试者进行了胃酸分泌研究。苯丙氨酸和色氨酸增强了低剂量五肽胃泌素后的胃酸分泌反应，而它们对低剂量组胺或胆碱能药物氨甲酰甲胆碱刺激的胃酸分泌的作用是相加的。苯丙氨酸和色氨酸不会增加五肽胃泌素、组胺或氨甲酰甲胆碱刺激的最大胃酸分泌量。能使五肽胃泌素刺激的胃酸分泌产生约50%抑制作用的H2受体拮抗剂雷尼替丁、前列腺素E1类似物米索前列醇、阿托品和生长抑素，显著抑制了苯丙氨酸和色氨酸刺激的胃酸分泌。苯丙氨酸或色氨酸与五肽胃泌素联合使用后，H2受体拮抗剂显著抑制胃酸分泌，而生长抑素、阿托品和前列腺素E1类似物则无效。这些结果表明，苯丙氨酸和色氨酸均能增强次最大剂量五肽胃泌素刺激的胃酸分泌，而它们对组胺和氨甲酰甲胆碱刺激的分泌的作用是相加的。苯丙氨酸和色氨酸对五肽胃泌素刺激的胃酸分泌的增强作用至少部分取决于完整的组胺途径。
