Leibman K C, Ortiz E
Drug Metab Dispos. 1978 Jul-Aug;6(4):375-8.
Hydroxylation of cyclohexene at the allylic position has been shown to occur in hepatic microsomes and 9000 g supernatant fractions of rats and rabbits. The formation of the product, 2-cyclohexen-1-ol, requires the presence of a NADPH-generating system, is inhibited by CO, metyrapone, and SKF 525-A, and is induced by pretreatment with phenobarbital. A small amount of 2-cyclohexen-1-one is also formed in preparations from phenobarbital-pretreated rats. No 2-cyclohexen-1-ol could be detected in the beta-glucuronidase-hydrolyzed urine of rats given cyclohexene orally; however, these rats excreted a small quantity of 2-cyclohexen-1-one.
已证实在大鼠和兔子的肝微粒体以及9000g上清液组分中，环己烯在烯丙基位置发生羟基化反应。产物2-环己烯-1-醇的形成需要存在一个生成NADPH的系统，受到一氧化碳、甲吡酮和SKF 525-A的抑制，并可通过苯巴比妥预处理诱导。在经苯巴比妥预处理的大鼠的制剂中也会形成少量的2-环己烯-1-酮。口服环己烯的大鼠经β-葡萄糖醛酸酶水解的尿液中未检测到2-环己烯-1-醇；然而，这些大鼠排泄出少量的2-环己烯-1-酮。
