突尼斯头状百里香精油和有机提取物的抗棘阿米巴活性。
Anti-Acanthamoeba activity of Tunisian Thymus capitatus essential oil and organic extracts.
作者信息
Saoudi Salma, Sifaoui Ines, Chammem Nadia, Reyes-Batlle María, López-Arencibia Atteneri, Pacheco-Fernández Idaira, Pino Verónica, Hamdi Moktar, Jiménez Ignacio A, Bazzocchi Isabel L, Piñero José E, Lorenzo-Morales Jacob
机构信息
Laboratoire d'Ecologie et de Technologie Microbiennes, Institut National des Sciences Appliquées et de Technologie, INSAT, University of Carthage, 2 Boulevard de la Terre, BP 676, 1080 Tunis, Tunisia.
Laboratoire Matériaux-Molécules et Applications, IPEST, University of Carthage, B.P. 51, 2070 La Marsa, Tunisia; University Institute of Tropical Diseases and Public Health, University of La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271 La Laguna, Tenerife, Canary Islands, Spain.
出版信息
Exp Parasitol. 2017 Dec;183:231-235. doi: 10.1016/j.exppara.2017.09.014. Epub 2017 Sep 12.
Acanthamoeba species are free-living amoebae widely distributed in the environment and which cause serious human infections. The treatment of Acanthamoeba infections is always very difficult and not constantly effective. More efficient drugs against Acanthamoeba must be developed and medicinal plants can be useful in this case. Our research focused on the examination of the anti-Acanthamoeba activity of the essential oil and the ethanolic-aqueous extract from Thymus capitatus L. The essential oil showed best activity with an IC of 2.73 μg/ml. The conducted Bio-guided fractionation of thyme extract result to the identification of two active compounds against the trophozoite stage of Acanthamoeba: thymol and 2,3-dihydroxy-p-cymene. The results have clearly shown that the investigated products may be successfully used against Acanthamoeba infections. These molecules that are found in plants may be an alternative for the development of new drugs.
棘阿米巴属是自由生活的变形虫，广泛分布于环境中，可导致严重的人类感染。棘阿米巴感染的治疗一直非常困难且效果不恒定。必须开发出更有效的抗棘阿米巴药物，在这种情况下药用植物可能会有所帮助。我们的研究集中于检查来自头状百里香的精油和乙醇 - 水提取物的抗棘阿米巴活性。精油表现出最佳活性，IC50为2.73μg/ml。对百里香提取物进行的生物导向分级分离鉴定出两种针对棘阿米巴滋养体阶段的活性化合物：百里香酚和2,3 - 二羟基对异丙基苯。结果清楚地表明，所研究的产品可能成功用于对抗棘阿米巴感染。在植物中发现的这些分子可能是开发新药的替代物。
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