Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, Université de Toulouse, UMR CNRS 5623, Université Paul-Sabatier, Toulouse, France.
J Food Sci. 2012 Aug;77(8):H184-91. doi: 10.1111/j.1750-3841.2012.02812.x.
Six essential oils (EOs), Juniperus phoenicea (leaves and berries), Thymus capitatus, Lauris nobilis, Melaleuca armillaris, and Eucalyptus gracilis, were screened for their antioxidant and antihypertensive activity as well as their chemical compositions. We identified and quantified 24 compounds (representing 99.8% of total oil) for J. phoenicea leaves, 14 compounds (representing 98.8% of total oil) for J. phoenicea berries, 11 compounds (representing 99.6% of total oil) for T. capitatus, 32 compounds (representing 98.9% of total oil) for L. nobilis, 32 compounds (representing 98.7% of total oil) for M. armillaris, and 26 compounds (representing 99.3% of total oil) for E. gracilis. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the antioxidant activity was in the range of 0.59 to 2183.6 mg/L, whereas T. capitatus (1.24 ± 0.05 mg/L) gave the best activity in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonate assay. Antihypertensive activity was evaluated by testing the vasorelaxing capacity of EOs on rat aorta precontracted by phenylephrine (10(-6) M). T. capitatus and L. nobilis were most active for an antihypertensive activity (29 ± 3 and 59 ± 2 mg/L, respectively). Correlations between chemical composition or antioxidant activity and/or antihypertensive activity were studied. Significant correlation has been found for antihypertensive activity and p-cymene (R(2) = 0.86), β-elemene (R(2) = 0.90), and β-myrcene (R(2) = 0.76). A good correlation has been found between antihypertensive activity and antioxidant activity by DPPH assay (R(2) = 0.98). Antioxidant activity can contribute to the prevention of the increase of the blood pressure. According to the literature, no study has been reported until now of correlation between antihypertensive activity and antioxidant activity. Natural EOs can find its interest and application in a medicinal area.
六种精油（EOs），包括杜松（叶和浆果）、香桃木、月桂、茶树、麦卢卡和桉树，因其抗氧化和降压活性以及化学成分而被筛选。我们鉴定并定量了 24 种化合物（代表总油的 99.8%）用于杜松叶，14 种化合物（代表总油的 98.8%）用于杜松浆果，11 种化合物（代表总油的 99.6%）用于香桃木，32 种化合物（代表总油的 98.9%）用于月桂，32 种化合物（代表总油的 98.7%）用于麦卢卡，26 种化合物（代表总油的 99.3%）用于桉树。在 1,1-二苯基-2-苦基肼（DPPH）测定中，抗氧化活性范围为 0.59 至 2183.6 mg/L，而香桃木（1.24 ± 0.05 mg/L）在 2,2'-联氮基-3-乙基苯并噻唑啉-6-磺酸测定中表现出最佳活性。通过测试 EO 对苯肾上腺素（10(-6) M）预收缩的大鼠主动脉的血管舒张能力来评估降压活性。香桃木和月桂的降压活性最强（分别为 29 ± 3 和 59 ± 2 mg/L）。研究了化学成分或抗氧化活性和/或降压活性之间的相关性。已经发现，降压活性与对伞花烃（R(2) = 0.86）、β-榄香烯（R(2) = 0.90）和β-月桂烯（R(2) = 0.76）之间存在显著相关性。通过 DPPH 测定法，已经发现降压活性和抗氧化活性之间存在良好的相关性（R(2) = 0.98）。抗氧化活性有助于预防血压升高。根据文献，直到现在，还没有报道过降压活性和抗氧化活性之间的相关性。天然 EO 可以在药用领域找到其兴趣和应用。
