儿童肾脏病专家和儿童风湿病专家对膜性狼疮性肾炎的处理方法的调查。
Approach to Membranous Lupus Nephritis: A Survey of Pediatric Nephrologists and Pediatric Rheumatologists.
机构信息
Columbia University Medical Center, New York, New York; Rady Children's Hospital, University of California San Diego, San Diego; University of California Los Angeles, Los Angeles; University of California San Francisco, San Francisco, California; Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia; Seattle Children's Hospital Research Institute, University of Washington, Seattle, Washington; Connecticut Children's Hospital, University of Connecticut, Hartford, Connecticut; Johns Hopkins University, Baltimore, Maryland; Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio; Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA; Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
A. Boneparth, MD, Assistant Professor of Pediatrics, Pediatric Rheumatologist, Columbia University Medical Center; S.M. Radhakrishna, MD, Assistant Clinical Professor of Pediatrics, Pediatric Rheumatologist, Rady Children's Hospital, University of California San Diego; L.A. Greenbaum, MD, PhD, Marcus Professor of Pediatrics, Pediatric Nephrologist, Children's Healthcare of Atlanta, Emory University; E. Yen, MD, Pediatric Rheumatology Fellow, University of California Los Angeles; D.M. Okamura, MD, Associate Professor of Pediatrics, Pediatric Nephrologist, Seattle Children's Hospital Research Institute, University of Washington; J.C. Cooper, MD, PharmD, Pediatric Rheumatology Fellow, University of California San Francisco; S. Mason, MD, MBA, Assistant Professor of Pediatrics, Pediatric Nephrologist, Connecticut Children's Hospital, University of Connecticut; D.M. Levy, MD, MS, FRCPC, Assistant Professor of Pediatrics, Pediatric Rheumatologist, Hospital for Sick Children, University of Toronto; S.D. Sule, MD, Associate Professor of Pediatrics, Pediatric Nephrologist, Johns Hopkins University; P.T. Jensen, MD, Pediatric and Adult Rheumatology Fellow, Nationwide Children's Hospital, The Ohio State University; C. Yildirim-Toruner, MD, Assistant Professor of Pediatrics, Pediatric Rheumatologist, Nationwide Children's Hospital, The Ohio State University; S.P. Ardoin, MD, Associate Professor of Medicine and Pediatrics, Pediatric Rheumatologist, Nationwide Children's Hospital, The Ohio State University; S.E. Wenderfer, MD, PhD, Assistant Professor of Pediatrics, Pediatric Nephrologist, Texas Children's Hospital, Baylor College of Medicine.
出版信息
J Rheumatol. 2017 Nov;44(11):1619-1623. doi: 10.3899/jrheum.170502. Epub 2017 Sep 15.
OBJECTIVE
To describe treatment practices for childhood pure membranous lupus nephritis (MLN).
METHODS
Survey study of Childhood Arthritis and Rheumatology Research Alliance and American Society of Pediatric Nephrology members.
RESULTS
There were 117 respondents who completed the survey (60 pediatric nephrologists, 57 pediatric rheumatologists). Steroids and nonsteroid immunosuppression (NSI) were routinely used by the majority for MLN. Mycophenolate mofetil was the favored initial NSI. Nephrologists used steroids (60% vs 93%) and NSI (53% vs 87%) less often than did rheumatologists for MLN without nephrotic syndrome (NS).
CONCLUSION
Pediatric rheumatologists and nephrologists both recommend steroids and NSI for children with MLN, with or without NS.
目的
描述儿童单纯膜性狼疮肾炎 (MLN) 的治疗方法。
方法
对儿童关节炎和风湿病研究联盟以及美国儿科肾脏病学会成员进行调查研究。
结果
共有 117 名受访者完成了调查（60 名儿科肾病专家，57 名儿科风湿病专家）。大多数人常规使用类固醇和非甾体免疫抑制剂 (NSI) 治疗 MLN。霉酚酸酯是首选的初始 NSI。对于没有肾病综合征 (NS) 的 MLN，肾病专家使用类固醇 (60% 比 93%) 和 NSI (53% 比 87%) 的频率低于风湿病专家。
结论
儿科风湿病专家和肾病专家都建议对有 MLN 的儿童使用类固醇和 NSI，无论是否有 NS。
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