特发性肺纤维化中肺癌的患病率、危险因素及生存率

Prevalence, risk factors and survival of lung cancer in the idiopathic pulmonary fibrosis.

作者信息

Lee Kyung Jong, Chung Man Pyo, Kim Young Whan, Lee Jae Ho, Kim Kyu-Sik, Ryu Jeong Seon, Lee Hong Lyeol, Park Sung Woo, Park Choon Sik, Uh Soo-Tak, Lee Yong Chul, Park Seoung Ju, Kim Kwan Hyoung, Jeon Young June, Choi Won Il, Park Yong Bum, Kim Dong Soon, Jeong Sung Hwan, Lee Jin Hwa, Park Moo Suk

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine, South Korea Department of Internal Medicine, Chonnam National University College of Medicine, South Korea Department of Internal Medicine, Inha University College of Medicine, South Korea Department of Internal Medicine, Soon Chun Hyang University College of Medicine, South Korea Department of Internal Medicine, Chonbuk National University College of Medicine, South Korea Department of Internal Medicine, Catholic University College of Medicine, South Korea Department of Internal Medicine, Keimyung University School of Medicine, South Korea Department of Internal Medicine, Hallym University College of Medicine, South Korea Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, South Korea Department of Internal Medicine, Gachon University College of Medicine, South Korea Department of Internal Medicine, Ewha Womans University College of Medicine, South Korea Department of Internal Medicine, Yonsei University College of Medicine, South Korea.

出版信息

Thorac Cancer. 2012 May;3(2):150-155. doi: 10.1111/j.1759-7714.2011.00107.x.

DOI:10.1111/j.1759-7714.2011.00107.x

PMID:28920300

Abstract

BACKGROUND

The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF).

METHODS

IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical records retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer in IPF patients.

RESULTS

Among all patients with IPF, 114 cases (6.8%) had lung cancer with IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100 person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%) were located in IPF-associated areas; the lung cancer typically developed in peripheral and lower lobe areas. The study revealed that forced vital capacity (% predicted) at the initial diagnosis and development of lung cancer were independent prognostic factors in patients with IPF.

CONCLUSIONS

Lung cancer in patients with IPF was significantly related with the IPF prognosis. An active evaluation should be performed in patients with IPF to detect lung cancer early.

摘要

背景

本研究旨在评估特发性肺纤维化（IPF）患者中肺癌的患病率、危险因素及生存率。

方法

来自三级医院的1685例IPF合并肺癌患者，均于2003年至2007年间确诊。我们回顾性分析了他们的病历，以评估IPF患者中肺癌的患病率、危险因素及预后。

结果

在所有IPF患者中，114例（6.8%）患有IPF合并肺癌。IPF患者中肺癌的发病率为每100人年1.03人（25例患者/2408人年）。大多数肺癌病例（73/114，68.9%）位于与IPF相关的区域；肺癌通常发生在周边和下叶区域。研究表明，初始诊断时及肺癌发生时的用力肺活量（预计值%）是IPF患者的独立预后因素。