Wu Hao, Zhong Rong-Ling, Xia Zhi, Huang Hou-Cai, Zhong Qing-Xiang, Feng Liang, Song Jie, Jia Xiao-Bin
Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, China.
Zhongguo Zhong Yao Za Zhi. 2016 Sep;41(17):3209-3217. doi: 10.4268/cjcmm20161715.
In recent years, the proportion of traditional Chinese medicine in scientific research and its clinical use increased gradually. The research result also becomes more and more valuable, but in the process of using traditional Chinese medicine, it also needs to pay more attention. With the gradual deepening of the toxicity of traditional Chinese medicine, some traditional Chinese medicines have also been found to have the potential toxicity, with the exception of some traditional toxicity Chinese medicine. Traditional Chinese medicine in the growth, processing, processing, transportation and other aspects of pollution or deterioration will also cause the side effects to the body. Clinical practice should be based on the theory of traditional Chinese medicine to guide rational drug use and follow the symptomatic medication, the principle of proper compatibility. The constitution of the patients are different, except for a few varieties of traditional Chinese medicines are natural herbs with hepatotoxicity, liver toxicity of most of the traditional Chinese medicine has idiosyncratic features. The liver plays an important role in drug metabolism. It is easy to be damaged by drugs. Therefore, the study of traditional Chinese medicine potential liver toxicity and its toxic components has become one of the basic areas of traditional Chinese medicine research. Based on the review of the literatures, this paper summarizes the clinical classification of liver toxicity, the pathogenesis of target cell injury, and systematically summarizes the mechanism of liver toxicity and toxic mechanism of traditional Chinese medicine. This paper provided ideas for the study of potential liver toxicity of traditional Chinese medicine and protection for clinical safety of traditional Chinese medicine.
近年来，中医药在科研及临床应用中的占比逐渐增加。其研究成果也越来越有价值，但在使用中医药的过程中，也需要更加注意。随着对中药毒性认识的逐渐深入，除了一些传统的有毒中药外，一些中药也被发现具有潜在毒性。中药在生长、加工炮制、运输等环节受到污染或变质也会对机体造成副作用。临床实践应依据中医理论指导合理用药，遵循辨证用药、配伍得当的原则。患者体质各异，除少数品种的天然中药具有肝毒性外，大多数中药的肝毒性具有个体特异性。肝脏在药物代谢中起着重要作用，容易受到药物损伤。因此，研究中药潜在肝毒性及其毒性成分已成为中医药研究的基础领域之一。本文通过文献综述，总结了肝毒性的临床分类、靶细胞损伤的发病机制，系统归纳了中药肝毒性的作用机制及毒性机制。本文为中药潜在肝毒性的研究及保障中药临床安全提供了思路。
