1 Centre for Neuro Skills Clinical Research and Education Foundation , Bakersfield, California.
2 Department of Neurosurgery, David Geffen School of Medicine at the University of California , Los Angeles, California.
J Neurotrauma. 2018 Jan 1;35(1):17-24. doi: 10.1089/neu.2017.5103. Epub 2017 Oct 27.
The acute and chronic effects of traumatic brain injury (TBI) have been widely described; however, there is limited knowledge on how a TBI sustained during early adulthood or mid-adulthood will influence aging. Epidemiological studies have explored whether TBI poses a risk for dementia and other neurodegenerative diseases associated with aging. We will discuss the influence of TBI and resulting medical comorbidities such as endocrine, sleep, and inflammatory disturbances on age-related gray and white matter changes and cognitive decline. Post mortem studies examining amyloid, tau, and other proteins will be discussed within the context of neurodegenerative diseases and chronic traumatic encephalopathy. The data support the suggestion that pathological changes triggered by an earlier TBI will have an influence on normal aging processes and will interact with neurodegenerative disease processes rather than the development of a specific disease, such as Alzheimer's or Parkinson's. Chronic neurophysiologic change after TBI may have detrimental effects on neurodegenerative disease.
创伤性脑损伤 (TBI) 的急性和慢性影响已被广泛描述；然而，对于成年早期或中期发生的 TBI 将如何影响衰老，我们知之甚少。 流行病学研究探讨了 TBI 是否会增加痴呆和其他与衰老相关的神经退行性疾病的风险。 我们将讨论 TBI 及其导致的内分泌、睡眠和炎症紊乱等医疗合并症对与年龄相关的灰质和白质变化以及认知能力下降的影响。 在神经退行性疾病和慢性创伤性脑病的背景下，将讨论检查淀粉样蛋白、tau 和其他蛋白质的死后研究。 这些数据支持以下观点，即早期 TBI 引发的病理变化将对正常衰老过程产生影响，并与神经退行性疾病过程相互作用，而不是发展为特定疾病，如阿尔茨海默病或帕金森病。 TBI 后的慢性神经生理变化可能对神经退行性疾病产生不利影响。
