空气污染暴露与自闭症谱系障碍儿童认知和适应功能及 ASD 严重程度的关系。
Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder.
机构信息
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, 624 N. Broadway, HH833, Baltimore, MD, 21205, USA.
出版信息
J Autism Dev Disord. 2018 Jan;48(1):137-150. doi: 10.1007/s10803-017-3304-0.
Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO), particulate matter (PM and PM), ozone, and near-roadway air pollution were assigned to each trimester of pregnancy and first year of life. Increasing prenatal and first year NO exposures were associated with decreased MSEL and VABS scores. Increasing PM exposure in the third trimester was paradoxically associated with improved performance on the VABS. ASD severity was not associated with air pollution exposure.
产前暴露于空气污染与自闭症谱系障碍（ASD）风险有关，但尚无研究探讨与 ASD 严重程度或功能的关联。使用 Mullen 早期学习量表（MSEL）、Vineland 适应行为量表（VABS）和自闭症诊断观察量表校准严重程度评分，对来自遗传与环境对儿童自闭症风险研究（Childhood Autism Risks from Genetics and the Environment study）中的 327 名 ASD 儿童的认知能力、适应功能和 ASD 严重程度进行了评估。为每个妊娠 trimester 和婴儿期分配了二氧化氮（NO）、颗粒物（PM 和 PM）、臭氧和路边空气污染的估计值。产前和婴儿期的 NO 暴露量增加与 MSEL 和 VABS 评分降低有关。第三 trimester 中 PM 暴露量的增加与 VABS 表现的改善呈反常相关。ASD 严重程度与空气污染暴露无关。
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