通过加速度测量评估维库溴铵对拇指和拇趾肌肉的不同作用。

Differential effects of vecuronium on the thumb and the big toe muscles evaluated by acceleration measurement.

作者信息

Kitajima Toshimitsu, Ishii Keiichi, Kobayashi Toshiya, Ogata Hiromaru

机构信息

First Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, 321-02, Shimotsugagun, Tochigi, Japan.

出版信息

J Anesth. 1994 Jun;8(2):143-145. doi: 10.1007/BF02514701.

DOI:10.1007/BF02514701

PMID:28921132

Abstract

To clarify the differential effects of vecuronium on the thumb and on the big toe, train-of-four (TOF) stimuli were applied to the ulnar nerve at the wrist and the tibial nerve at the ankle in anesthetized patients using two acceleration transducers. Ten adult patients, aged 21-55 years, were studied. Anesthesia was induced by an intravenous injection of thiopental, and vecuronium 0.1 mg·kg was used for paralysis. Anesthesia was maintained with nitrous oxide (66%)-oxygen-sevoflurane (1 MAC). The duration of time to the maximal twitch depression on the thumb and the big toe was 136.5±32.5 s and 183.0±40.1 s (P<0.05), respectively. The time to 25% recovery of the twitch height on the thumb and the big toe was 48.1±17.3 min and 39.1±11.6 min, respectively; the time to 50% recovery of twitch height on the thumb and the big toe was 54.1±16.1 min and 40.0±9.2 min (P<0.05), respectively. When paralysis was reversed at 25% of TOF ratio on the thumb, the value of the TOF ratio on the big toe was 58.5±18.2% (P<0.01).

摘要

为阐明维库溴铵对拇指和拇趾的不同作用，在麻醉患者中使用两个加速度换能器，分别对腕部的尺神经和踝部的胫神经施加四个成串刺激（TOF）。研究了10例年龄在21至55岁之间的成年患者。通过静脉注射硫喷妥钠诱导麻醉，使用0.1mg·kg的维库溴铵进行肌松。用氧化亚氮（66%）-氧气-七氟醚（1MAC）维持麻醉。拇指和拇趾达到最大抽搐抑制的时间分别为136.5±32.5秒和183.0±40.1秒（P<0.05）。拇指和拇趾抽搐高度恢复至25%的时间分别为48.1±17.3分钟和39.1±11.6分钟；拇指和拇趾抽搐高度恢复至50%的时间分别为54.1±16.1分钟和40.0±9.2分钟（P<0.05）。当拇指的四个成串刺激比值恢复至25%时进行肌松逆转，此时拇趾的四个成串刺激比值为58.5±18.2%（P<0.01）。